Manifesto on inhaled triple therapy in asthma: an Interasma (Global Asthma Association - GAA) document

Fulvio Braido^{1

2}, Angelica Tiotiu^{3

4}, Guillermo Guidos-Fogelbach⁵, Ilaria Baiardini^{2

6

7}, Filippo Cosini⁸, Jaime Correia de Sousa^{9

10}, Andras Bikov^{11

12}, Sylvia Novakova¹³, Marina Labor¹⁴, Igor Kaidashev¹⁵, Denislava Nedeva¹⁶, Krzysztof Kowal¹⁷, Stefan Mihaicuta¹⁸, Marilyn Urrutia Pereira¹⁹, Dirceu Solé²⁰, Plamela Novakova²¹, Herberto Chong-Neto²², Laura Vrzy⁸, Ignacio J Ansotegui²³, Jonathan A Bernstein²⁴, Louis-Philippe Boulet²⁵, Giorgio Walter Canonica^{6

7

26}, Lawrence Dubuske²⁷, Carlos Nunes²⁸, Juan Carlos Ivancevich²⁹, Pierachille Santus³⁰, Nelson Rosario³¹, Alexander Emelyanov³², Paschalis Steiropoulos³³

Affiliations

¹ IRCCS, Ospedale Policlinico San Martino, Genova, Italy.
² Department of Internal Medicine, University of Genoa, Genova, Italy.
³ Department of Pulmonology, University Hospital of Nancy, Nancy, France.
⁴ EA 3450 DevAH - Development, Adaptation and Disadvantage, Cardiorespiratory Regulations and Motor Control, University of Lorraine, Nancy, France.
⁵ Instituto Politécnico Nacional, E.N.M.H/S.E.P.I, Laboratorio de Bioquímica Estructural, Ciudad de México, México.
⁶ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
⁷ IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
⁸ University of Genoa, Genova, Italy.
⁹ Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
¹⁰ ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
¹¹ Manchester University NHS Foundation Trust, Manchester, UK.
¹² Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.
¹³ Allergy Unit of Internal Consulting Department, University Hospital "St. George", Plovdiv, Bulgaria.
¹⁴ Värnamo Hospital, Värnamo, Sweden.
¹⁵ Ukrainian Medical Stomatological Academy, Poltava, Ukraine.
¹⁶ Medical University Sofia, Sofia, Bulgaria.
¹⁷ Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
¹⁸ Pulmonology Department, Cardio Prevent Foundation, University of Medicine and Pharmacy "Dr Victor Babes", Timisoara, Romania.
¹⁹ Federal University of Pampa - Campus Uruguaiana, Pediatic Program of Asthma Prevention (PIPA), Pontifícia Universidade Católica do Rio Grande do Sul, Universidad Nacional de Córdoba, Córdoba, Argentina.
²⁰ Associação Brasileira de Alergia e Imunologia, Sociedade Brasileira de Pediatria, Universidade Federal de São Paulo, São Paulo, Brazil.
²¹ Clinic of Clinical Allergy, Medical University, Sofia, Bulgaria.
²² Division of Allergy and Immunology, Department of Pediatrics, Federal University of Paraná, Curitiba, Brazil.
²³ Hospital Quirónsalud Bizkaia, Bilbao, Spain.
²⁴ Division of Immunology, Department of Internal Medicine, Allergy Section University of Cincinnati, Cincinnati, OH, USA.
²⁵ Québec Heart and Lung Institute-Laval University, Québec City, Canada.
²⁶ Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
²⁷ Division of Allergy and Immunology, Department of Internal Medicine, George Washington University School of Medicine and Health Sciences, George Washington University Medical Faculty Associates, Washington, DC, USA.
²⁸ Centro de ImmunoAlergologia de Algarve, Porto, Portugal.
²⁹ Immunology Department, Faculty of Medicine, del Salvador University, Buenos Aires, Argentina.
³⁰ Department of Biomedical and Clinical Sciences, University of Milan, Division of Respiratory Diseases "L. Sacco" Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.
³¹ Federal University of Paraná (UFPR), Curitiba, Brazil.
³² Department of Respiratory Medicine, North-Western Medical University named after I.I.Mechnikov, St-Petersburg, Russia.
³³ Department of Respiratory Medicine, Medical School, Democritus University of Thrace, University General Hospital Dragana, Alexandroupolis, Greece.

PMID: 34936532
DOI: 10.1080/02770903.2021.2022160

Manifesto on inhaled triple therapy in asthma: an Interasma (Global Asthma Association - GAA) document

Fulvio Braido et al. J Asthma. 2022 Dec.

. 2022 Dec;59(12):2402-2412.

doi: 10.1080/02770903.2021.2022160. Epub 2022 Jan 11.

Authors

Affiliations

¹ IRCCS, Ospedale Policlinico San Martino, Genova, Italy.
² Department of Internal Medicine, University of Genoa, Genova, Italy.
³ Department of Pulmonology, University Hospital of Nancy, Nancy, France.
⁴ EA 3450 DevAH - Development, Adaptation and Disadvantage, Cardiorespiratory Regulations and Motor Control, University of Lorraine, Nancy, France.
⁵ Instituto Politécnico Nacional, E.N.M.H/S.E.P.I, Laboratorio de Bioquímica Estructural, Ciudad de México, México.
⁶ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
⁷ IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
⁸ University of Genoa, Genova, Italy.
⁹ Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
¹⁰ ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
¹¹ Manchester University NHS Foundation Trust, Manchester, UK.
¹² Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.
¹³ Allergy Unit of Internal Consulting Department, University Hospital "St. George", Plovdiv, Bulgaria.
¹⁴ Värnamo Hospital, Värnamo, Sweden.
¹⁵ Ukrainian Medical Stomatological Academy, Poltava, Ukraine.
¹⁶ Medical University Sofia, Sofia, Bulgaria.
¹⁷ Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
¹⁸ Pulmonology Department, Cardio Prevent Foundation, University of Medicine and Pharmacy "Dr Victor Babes", Timisoara, Romania.
¹⁹ Federal University of Pampa - Campus Uruguaiana, Pediatic Program of Asthma Prevention (PIPA), Pontifícia Universidade Católica do Rio Grande do Sul, Universidad Nacional de Córdoba, Córdoba, Argentina.
²⁰ Associação Brasileira de Alergia e Imunologia, Sociedade Brasileira de Pediatria, Universidade Federal de São Paulo, São Paulo, Brazil.
²¹ Clinic of Clinical Allergy, Medical University, Sofia, Bulgaria.
²² Division of Allergy and Immunology, Department of Pediatrics, Federal University of Paraná, Curitiba, Brazil.
²³ Hospital Quirónsalud Bizkaia, Bilbao, Spain.
²⁴ Division of Immunology, Department of Internal Medicine, Allergy Section University of Cincinnati, Cincinnati, OH, USA.
²⁵ Québec Heart and Lung Institute-Laval University, Québec City, Canada.
²⁶ Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
²⁷ Division of Allergy and Immunology, Department of Internal Medicine, George Washington University School of Medicine and Health Sciences, George Washington University Medical Faculty Associates, Washington, DC, USA.
²⁸ Centro de ImmunoAlergologia de Algarve, Porto, Portugal.
²⁹ Immunology Department, Faculty of Medicine, del Salvador University, Buenos Aires, Argentina.
³⁰ Department of Biomedical and Clinical Sciences, University of Milan, Division of Respiratory Diseases "L. Sacco" Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.
³¹ Federal University of Paraná (UFPR), Curitiba, Brazil.
³² Department of Respiratory Medicine, North-Western Medical University named after I.I.Mechnikov, St-Petersburg, Russia.
³³ Department of Respiratory Medicine, Medical School, Democritus University of Thrace, University General Hospital Dragana, Alexandroupolis, Greece.

PMID: 34936532
DOI: 10.1080/02770903.2021.2022160

Abstract

Objective: The optimal use of drug combinations for the management of asthma is providing significant results. This has prompted Interasma (Global Asthma Association) to take a position on inhaled triple therapy in asthma.Methods: We performed an extensive literature research to clinical trials, meta-analyses, randomized controlled trials and systematic reviews.Results: Starting from an extensive literature review, Interasma executive committee discussed and approved this Manifesto, developed by Interasma scientific network (INES) members.Conclusions: The manifesto describes the evidence gathered to date and states, advocates, and proposes issues on inhaled corticosteroid (ICS) plus long-acting beta 2 agonist (LABA) and long-acting muscarinic antagonists (LAMA) with the aim of challenging assumptions, fostering commitment, and bringing about change.

Keywords: Asthma management; Interasma; asthma control; asthma pharmacotherapy; asthma treatment; consensus; manifesto.

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Manifesto on inhaled triple therapy in asthma: an Interasma (Global Asthma Association - GAA) document

Affiliations

Manifesto on inhaled triple therapy in asthma: an Interasma (Global Asthma Association - GAA) document

Authors

Affiliations

Abstract

MeSH terms

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LinkOut - more resources

Full Text Sources

Medical

Miscellaneous