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. 2021 Dec 28;118(52):e2121094118.
doi: 10.1073/pnas.2121094118.

Inner Workings: Using vaccines to harness the immune system and fight drugs of abuse

Leah Shaffer

Inner Workings: Using vaccines to harness the immune system and fight drugs of abuse

Leah Shaffer. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

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One way to address opioid addiction is by using antibodies to destroy opioid molecules before they ever reach brain receptors, such as the mu-opioid receptor illustrated here. Image credit: Science Source/NANOCLUSTERING.
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The opioid epidemic has come in waves, ravaging large swaths of the United States. Image credit: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control.
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Lethal doses of heroin, carfentanil, and fentanyl (Left to Right) equate to very different amounts. Image credit: United States Drug Enforcement Administration.
See this image and copyright information in PMC

References

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    1. Laudenbach M., et al. , The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse. J. Immunol. 194, 5926–5936 (2015). - PMC - PubMed
    1. Smith L. C., et al. , Monoclonal antibodies for combating synthetic opioid intoxication. J. Am. Chem. Soc. 141, 10489–10503 (2019). - PMC - PubMed

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