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Comment
. 2021 Dec 22;6(1):436.
doi: 10.1038/s41392-021-00846-3.

"Moonlighting" at the power plant: how mitochondria facilitate serial killing by CD8+ cytotoxic T cells

Dimitrios Mougiakakos  1 , Sascha Kahlfuss  2   3   4   5
Affiliations
Comment

"Moonlighting" at the power plant: how mitochondria facilitate serial killing by CD8+ cytotoxic T cells

Dimitrios Mougiakakos et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Sustained killing by CD8+ CTLs needs mitochondrial translation. During serial killing of malignant target cells (wild type) CD8+ CTLs have a high-energy demand to meet, amongst other processes, their increased protein synthesis (i.e., proteome remodeling). Mitochondrial translation and so-called RNA-binding “moonlight” proteins support cytosolic translation of cytolytic proteins (i.e., Perforin and Granzymes) and tumoricidal cytokines including IFN-γ and TNF-α (upper panel). Deletion of USP-30 in CD8+ CTLs impacted mitochondrial ultrastructure and mitochondrial translation that elicited the selective mitigation of cytosolic translation of cytolytic proteins and of tumoricidal cytokines cumulating in tumor cell proliferation and cancer progression (lower panel)
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References

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