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. 2022 Feb;9(1):345-352.
doi: 10.1002/ehf2.13746. Epub 2021 Dec 22.

Prognostic value of cartilage intermediate layer protein 1 in chronic heart failure

Can Wang  1 , Wen Jian  1 , Qiuhu Luo  1 , Jiasheng Cui  1 , Yali Qing  1 , Chunyu Qin  1 , Gaoye Li  1 , Wuxian Chen  1
Affiliations

Prognostic value of cartilage intermediate layer protein 1 in chronic heart failure

Can Wang et al. ESC Heart Fail. 2022 Feb.

Abstract

Aims: Emerging evidence suggests that cartilage intermediate layer protein 1 (CILP-1) is associated with myocardial remodelling. However, the prognostic value of circulating CILP-1 in patients with heart failure (HF) remains to be elucidated. This study aimed to investigate whether circulating CILP-1 can independently predict the outcome of chronic HF.

Methods and results: This prospective cohort study included 210 patients with chronic HF and left ventricular ejection fraction <50% between September 2018 and December 2019. The primary endpoint was 1 year all-cause mortality. During the 1 year follow-up, 28 patients died. In multivariable Cox proportional hazards regression analysis, higher CILP-1 levels were independently associated with a higher risk of mortality after adjusting for potential confounding factors. In Kaplan-Meier analysis, patients with CILP-1 levels above the median had a significantly higher mortality rate than those with CILP-1 levels below the median (log-rank P = 0.015). In addition, CILP-1 significantly improved prognostic prediction over N-terminal pro-brain natriuretic peptide by an increase in net reclassification improvement (P = 0.043) and a trend towards an increase in integrated discrimination improvement (P = 0.118).

Conclusions: Circulating CILP-1 is a novel independent prognostic predictor in chronic HF.

Keywords: Biomarker; CILP-1; Heart failure; Prognosis.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Kaplan–Meier survival curves of 1 year all‐cause mortality in patients grouped according to median cartilage intermediate layer protein 1 (CILP‐1) level.
Figure 2
Figure 2
Receiver operating characteristic curve analysis of cartilage intermediate layer protein 1 (CILP‐1) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) for predicting 1 year all‐cause mortality. AUC, area under the receiver operating characteristic curve; CI, confidence interval.
See this image and copyright information in PMC

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