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Comparative Study
. 2021 Dec 23;385(26):2489-2491.
doi: 10.1056/NEJMc2102507. Epub 2021 Dec 1.

Viral Dynamics of SARS-CoV-2 Variants in Vaccinated and Unvaccinated Persons

Stephen M Kissler  1 , Joseph R Fauver  2 , Christina Mack  3 , Caroline G Tai  3 , Mallery I Breban  2 , Anne E Watkins  2 , Radhika M Samant  3 , Deverick J Anderson  4 , Jessica Metti  5 , Gaurav Khullar  5 , Rachel Baits  5 , Matthew MacKay  5 , Daisy Salgado  5 , Tim Baker  5 , Joel T Dudley  5 , Christopher E Mason  5 , David D Ho  6 , Nathan D Grubaugh  2 , Yonatan H Grad  7
Affiliations
Comparative Study

Viral Dynamics of SARS-CoV-2 Variants in Vaccinated and Unvaccinated Persons

Stephen M Kissler et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Cycle Threshold (Ct) Counts and Infection Clearance Time.
Shown are Ct counts for participants infected with the alpha variant (Panel A), delta variant (Panel B), and variants that were not of current interest or concern (non–VOI/VOCs) (Panel C). Also shown are Ct counts among unvaccinated participants (Panel D) and vaccinated participants (Panel E). Data points for Ct counts that were obtained after the conclusion of a participant’s acute infection (as measured by the mean posterior infection clearance time) are partially transparent, since this period was not the focus of the study. The mean posterior viral trajectories are depicted as solid lines with 95% credible intervals indicated by the shaded regions. Also shown are individual-level posterior means for the peak viral load according to variant status (Panel F) and the mean clearance time according to vaccination status (Panel G). In Panels F and G, horizontal lines indicate means and 𝙸 bars 95% credible intervals.
See this image and copyright information in PMC

References

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    1. Li B, Deng A, Li K, et al. Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 delta variant. July 23, 2021. (https://www.medrxiv.org/content/10.1101/2021.07.07.21260122v2). preprint. - PMC - PubMed
    1. Chia PY, Ong SWX, Chiew CJ, et al. Virological and serological kinetics of SARS-CoV-2 delta variant vaccine-breakthrough infections: a multi-center cohort study. July 31, 2021. (https://www.medrxiv.org/content/10.1101/2021.07.28.21261295v1). preprint. - PMC - PubMed
    1. Hay JA, Kennedy-Shaffer L, Kanjilal S, et al. Estimating epidemiologic dynamics from cross-sectional viral load distributions. Science 2021;373:eabh0635-eabh0635. - PMC - PubMed
    1. Kissler SM, Fauver JR, Mack C, et al. Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies. PLoS Biol 2021;19(7):e3001333-e3001333. - PMC - PubMed

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