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Comment
. 2021 Dec 24;374(6575):1559-1560.
doi: 10.1126/science.abn0399. Epub 2021 Dec 23.

Fibrin sparks inflammation in the oral mucosa

Tommaso Vicanolo  1 , Andrés Hidalgo  1
Affiliations
Comment

Fibrin sparks inflammation in the oral mucosa

Tommaso Vicanolo et al. Science. .

Abstract

Fibrin deposits in the oral mucosa trigger neutrophil activation and bone destruction.

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  • Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier.
    Silva LM, Doyle AD, Greenwell-Wild T, Dutzan N, Tran CL, Abusleme L, Juang LJ, Leung J, Chun EM, Lum AG, Agler CS, Zuazo CE, Sibree M, Jani P, Kram V, Martin D, Moss K, Lionakis MS, Castellino FJ, Kastrup CJ, Flick MJ, Divaris K, Bugge TH, Moutsopoulos NM. Silva LM, et al. Science. 2021 Dec 24;374(6575):eabl5450. doi: 10.1126/science.abl5450. Epub 2021 Dec 24. Science. 2021. PMID: 34941394 Free PMC article.

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