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Comment
. 2021 Dec 22;184(26):6224-6226.
doi: 10.1016/j.cell.2021.11.035.

Caging NLRP3 tames inflammasome activity

Kate Schroder  1 , Rebecca C Coll  2
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Caging NLRP3 tames inflammasome activity

Kate Schroder et al. Cell. .
Free article

Abstract

How the danger sensor NLRP3 is activated is intensively debated. Using cryo-electron microscopy (EM) approaches, Andreeva and colleagues made the remarkable discovery that inactive NLRP3 forms a double ring of 12-16 monomers that shield its pyrin domains from the cytosol. We discuss this surprising new mechanism of inflammasome regulation.

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Conflict of interest statement

Declaration of interests K.S. and R.C.C. are co-inventors on patent applications for NLRP3 inhibitors which have been licensed to Inflazome Ltd. K.S. served on the Scientific Advisory Board of Inflazome in 2016–2017 and is a consultant for Quench Bio and Novartis. R.C.C. is a consultant for BioAge Labs.

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