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Review
. 2021 Nov 26;11(12):2210.
doi: 10.3390/diagnostics11122210.

Host Defence Peptides in Diabetes Mellitus Type 2 Patients with Periodontal Disease. A Systematic Review

Muhammad Saad Shaikh  1 , Muhammad Sohail Zafar  2   3 , Farhan Saleem  4 , Ahmad Alnazzawi  5 , Mohid Abrar Lone  6 , Syed Jawad Ali Bukhari  7 , Zohaib Khurshid  8
Affiliations
Review

Host Defence Peptides in Diabetes Mellitus Type 2 Patients with Periodontal Disease. A Systematic Review

Muhammad Saad Shaikh et al. Diagnostics (Basel). .

Abstract

The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific key phrases to search the electronic databases PubMed (National Library of Medicine), Embase (Ovid), Medline (EBSCO), and Dentistry and Oral Sciences (EBSCO). Quality assessment was conducted by means of the Newcastle Ottawa scale and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Following a thorough screening process, a total of 12 papers (4 case-control, 6 cross-sectional, 1 animal, and 1 in vitro) fulfilled the selection criteria and were included. The majority of research found that HDPs were upregulated in DM2 patients with PD. Three investigations, however, found that HDPs were downregulated in DM2 patients with PD. HDPs play a part in the pathophysiology of PD and DM2. Nonetheless, more human, animal and laboratory investigations are needed to fully understand validation of the link, as the evidence is limited. Understanding HDPs as common moderators is critical, aimed at unlocking their potential as therapeutic and diagnostic agents.

Keywords: antimicrobial peptides; diabetes mellitus; periodontal disease; risk factor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Search strategy used to search articles.
Figure 2
Figure 2
Quality appraisal of case-control studies via Newcastle Ottawa scale. A study can be awarded a maximum of one star (*) for each numbered item within the Selection and Exposure categories. A maximum of two stars can be given for Comparability.
Figure 3
Figure 3
Quality appraisal of cross-sectional studies via modified Newcastle Ottawa scale. A study can be awarded a maximum of one star (*) for each numbered item within the Comparability categories. A maximum of five stars can be given for the Selection category (two stars for the Ascertainment of the exposure) and three stars can be given for the Outcome category (two stars for the Assessment of outcome).
Figure 4
Figure 4
Quality appraisal of animal study via SYRCLE tool.
See this image and copyright information in PMC

References

    1. Meyle J., Chapple I. Molecular aspects of the pathogenesis of periodontitis. Periodontology 2000. 2015;69:7–17. doi: 10.1111/prd.12104. - DOI - PubMed
    1. Gorr S.-U. Antimicrobial peptides in periodontal innate defense. J. Clin. Periodontol. 2012;15:84–98. - PMC - PubMed
    1. Diamond G., Beckloff N., Weinberg A., Kisich K.O. The roles of antimicrobial peptides in innate host defense. Curr. Pharm. Des. 2009;15:2377–2392. doi: 10.2174/138161209788682325. - DOI - PMC - PubMed
    1. Last N.B., Schlamadinger D.E., Miranker A.D. A common landscape for membrane-active peptides. Protein Sci. 2013;22:870–882. doi: 10.1002/pro.2274. - DOI - PMC - PubMed
    1. Gorr S.U., Abdolhosseini M. Antimicrobial peptides and periodontal disease. J. Clin. Periodontol. 2011;38:126–141. doi: 10.1111/j.1600-051X.2010.01664.x. - DOI - PubMed

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