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Review
. 2021 Dec 8;10(12):1508.
doi: 10.3390/antibiotics10121508.

Global Prevalence of Nosocomial Multidrug-Resistant Klebsiella pneumoniae: A Systematic Review and Meta-Analysis

Nur Ain Mohd Asri  1   2 , Suhana Ahmad  3 , Rohimah Mohamud  3 , Nurmardhiah Mohd Hanafi  2 , Nur Fatihah Mohd Zaidi  1 , Ahmad Adebayo Irekeola  4 , Rafidah Hanim Shueb  4 , Leow Chiuan Yee  5 , Norhayati Mohd Noor  6 , Fatin Hamimi Mustafa  1 , Chan Yean Yean  1   4 , Nik Yusnoraini Yusof  1
Affiliations
Review

Global Prevalence of Nosocomial Multidrug-Resistant Klebsiella pneumoniae: A Systematic Review and Meta-Analysis

Nur Ain Mohd Asri et al. Antibiotics (Basel). .

Abstract

The emergence of nosocomial multidrug-resistant Klebsiella pneumoniae is an escalating public health threat worldwide. The prevalence of nosocomial infections due to K. pneumoniae was recorded up to 10%. In this systematic review and meta-analysis, which were conducted according to the guidelines of Preferred Reporting Items for Systematic Review and Meta-Analysis, 1092 articles were screened from four databases of which 47 studies fulfilled the selected criteria. By performing a random-effect model, the pooled prevalence of nosocomial multidrug-resistant K. pneumoniae was estimated at 32.8% (95% CI, 23.6-43.6), with high heterogeneity (I2 98.29%, p-value < 0.001). The estimated prevalence of this pathogen and a few related studies were discussed, raising awareness of the spread of multidrug-resistant K. pneumoniae in the healthcare setting. The emergence of nosocomial multidrug-resistant K. pneumoniae is expected to increase globally in the future, and the best treatments for treating and preventing this pathogen should be acknowledged by healthcare staff.

Keywords: Klebsiella pneumoniae; antibiotic resistance; meta-analysis; multidrug-resistant; nosocomial; prevalence; systematic review; worldwide.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram illustrating the selection process of the studies in this analysis.
Figure 2
Figure 2
Percentage of resistance according to (A) antibiotic classes and (B) resistance genes in the included studies.
Figure 3
Figure 3
Forest plot of the prevalence of nosocomial MDR K. pneumoniae. The prevalence of reported nosocomial MDR K. pneumoniae cases was estimated by a random-effect model using the DerSimonian-Laird method of meta-analysis.
Figure 4
Figure 4
Funnel plot showing the evidence of publication bias with Egger’s test (p-value < 0.001).
See this image and copyright information in PMC

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