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Review
. 2021 Dec 14;10(12):3529.
doi: 10.3390/cells10123529.

Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment

Ainhoa Hernández  1 , Marta Domènech  1 , Ana M Muñoz-Mármol  2 , Cristina Carrato  2 , Carmen Balana  1
Affiliations
Review

Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment

Ainhoa Hernández et al. Cells. .

Abstract

Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are two main elements that influence tumor immune cells and TME. In this manuscript, we review how both factors can contribute to an immunosuppressive state and overview the strategies being tested.

Keywords: glioblastoma; metabolism; microenvironment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Glutamine and D2-Hydroxyglutarate metabolism in IDH mutant.
See this image and copyright information in PMC

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