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. 2021 Dec 9;10(24):5762.
doi: 10.3390/jcm10245762.

Healing of Chronic Wounds with Platelet-Derived Growth Factors from Single Donor Platelet-Rich Plasma following One Freeze-Thaw Cycle. A Cross-Sectional Study

Julia Vidán-Estévez  1   2 , Sergio Sánchez-Herráez  3 , Fernando Escalante-Barrigón  4 , Jesús Seco-Calvo  5   6
Affiliations

Healing of Chronic Wounds with Platelet-Derived Growth Factors from Single Donor Platelet-Rich Plasma following One Freeze-Thaw Cycle. A Cross-Sectional Study

Julia Vidán-Estévez et al. J Clin Med. .

Abstract

Chronic non-healing wounds (CNHWs) may be associated with trauma or idiopathic in nature and are difficult to treat. Our objective was to assess the use of platelet-derived growth factor (PDGF) from single-donor platelets (al-PRP), using one freeze-thaw cycle, for treating CNHWs. We conducted a cross-sectional study. A total of 23 CNHWs being treated with al-PRP. The al-PRP treatment can be considered successful in well over half (n = 13, 56.5%) of the wounds. We found that all the wounds treated for up to 7 weeks showed partial or complete healing, while those treated for between 8 and 12 weeks did not show healing, healing again being successful in cases in which treatment was extended to more than 13 weeks (85.7%). Using chi-square tests, this relationship was found to be highly significant (p < 0.001, chi2 = 19.51; p value = 0.00006). Notably, Cramer's V coefficient was very high (0.921), indicating that the effect size of PRP treatment duration on healing is very large (84.8%). We could suggest that the use of al-PRP in the healing of CNHWs is a promising approach. Further studies with larger sample sizes and long follow-ups are needed to obtain multivariate models to explain which factors favour the healing of ulcers treated with PRP.

Keywords: al-PRP; chronic; non-healing wounds; platelet-derived growth factor (PDGF).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of patients included in the study.
Figure 2
Figure 2
Example of wound healed completely (left, week 0; middle, week 7; right, week 12).
Figure 3
Figure 3
Example of wound healed partially. (A). Week 0. Example of wound healed partially. (B) Week 4. Example of wound healed partially. (C) Week 16.
Figure 3
Figure 3
Example of wound healed partially. (A). Week 0. Example of wound healed partially. (B) Week 4. Example of wound healed partially. (C) Week 16.
See this image and copyright information in PMC

References

    1. Brod M. Quality of life issues in patients with diabetes and lower extremity ulcers: Patients and care givers. Qual Life Res. 1998;7:365–372. doi: 10.1023/A:1008836325782. - DOI - PubMed
    1. Singh N., Armstrong D.G., Lipsky B.A. Preventing foot ulcers in patients with diabetes. JAMA. 2005;293:217–228. doi: 10.1001/jama.293.2.217. - DOI - PubMed
    1. Garber S.L., Rintala D.H. Pressure ulcers in veterans with spinal cord injury: A retrospective study. J. Rehabil. Res. Dev. 2003;40:433–441. doi: 10.1682/JRRD.2003.09.0433. - DOI - PubMed
    1. Medina A., Scott P.G., Ghahary A., Tredget E.E. Pathophysiology of chronic nonhealing wounds. J. Burn Care Rehabil. 2005;26:306–319. doi: 10.1097/01.BCR.0000169887.04973.3A. - DOI - PubMed
    1. Brtan Romić R., Brtan A., Romić I., Cvitanović H., Duvančić T., Lugović-Mihić L. Quality of life and perception of disease in patients with chronic leg ulcer. Acta Clin. Croat. 2015;54:309–314. - PubMed

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