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. 2021 Dec 13;10(24):5818.
doi: 10.3390/jcm10245818.

SARS-CoV-2 Infection in Patients on Dialysis: Incidence and Outcomes in the Lazio Region, Italy

Claudia Marino  1 , Laura Angelici  1 , Valentina Pistolesi  2 , Santo Morabito  2 , Anteo Di Napoli  3 , Enrico Calandrini  1 , Silvia Cascini  1 , Anna Maria Bargagli  1 , Nicola Petrosillo  4 , Nera Agabiti  1 , Marina Davoli  1 , On Behalf Of The Regional Registry Dialysis And Transplant Lazio Region
Affiliations

SARS-CoV-2 Infection in Patients on Dialysis: Incidence and Outcomes in the Lazio Region, Italy

Claudia Marino et al. J Clin Med. .

Abstract

Patients with end-stage kidney disease represent a frail population and might be at higher risk of SARS-CoV-2 infection. The Lazio Regional Dialysis and Transplant Registry collected information on dialysis patients with a positive swab. The study investigated incidence of SARS-CoV-2 infection, mortality and their potential associated factors in patients undergoing maintenance hemodialysis (MHD) in the Lazio region. Method: The occurrence of infection was assessed among MHD patients included in the RRDTL from 1 March to 30 November 2020. The adjusted cumulative incidence of infection and mortality risk within 30 days of infection onset were estimated. Logistic and Cox regression models were applied to identify factors associated with infection and mortality, respectively. Results: The MHD cohort counted 4942 patients; 256 (5.2%) had COVID-19. The adjusted cumulative incidence was 5.1%. Factors associated with infection included: being born abroad, educational level, cystic renal disease/familial nephropathy, vascular disease and being treated in a dialysis center located in Local Health Authority (LHA) Rome 2. Among infected patients, 59 (23.0%) died within 30 days; the adjusted mortality risk was 21.0%. Factors associated with 30-day mortality included: age, malnutrition and fever at the time of swab. Conclusions: Factors associated with infection seem to reflect socioeconomic conditions. Factors associated with mortality, in addition to age, are related to clinical characteristics and symptoms at the time of swab.

Keywords: COVID-19; SARS-CoV-2 infection; end-stage kidney disease; hemodialysis; incidence; mortality; outcome.

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Conflict of interest statement

The authors declare that they have no conflicts of interests.

Figures

Figure 1
Figure 1
Flowchart to assess the completeness of the “RRDTL COVID-19 section”.
Figure 2
Figure 2
Factors associated with SARS-CoV-2 infection among hemodialysis patients.
Figure 3
Figure 3
Factors associated with 30-day mortality in hemodialysis patients infected with SARS-CoV-2.
See this image and copyright information in PMC

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