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Review
. 2021 Dec 18;10(24):5947.
doi: 10.3390/jcm10245947.

The Role of Extracellular Matrix in Skin Wound Healing

Nikolai N Potekaev  1 , Olga B Borzykh  2 , German V Medvedev  3 , Denis V Pushkin  4 , Marina M Petrova  2 , Artem V Petrov  2 , Diana V Dmitrenko  2 , Elena I Karpova  1 , Olga M Demina  1 , Natalia A Shnayder  2   5
Affiliations
Review

The Role of Extracellular Matrix in Skin Wound Healing

Nikolai N Potekaev et al. J Clin Med. .

Abstract

Impaired wound healing is one of the unsolved problems of modern medicine, affecting patients' quality of life and causing serious economic losses. Impaired wound healing can manifest itself in the form of chronic skin wounds or hypertrophic scars. Research on the biology and physiology of skin wound healing disorders is actively continuing, but, unfortunately, a single understanding has not been developed. The attention of clinicians to the biological and physiological aspects of wound healing in the skin is necessary for the search for new and effective methods of prevention and treatment of its consequences. In addition, it is important to update knowledge about genetic and non-genetic factors predisposing to impaired wound healing in order to identify risk levels and develop personalized strategies for managing such patients. Wound healing is a very complex process involving several overlapping stages and involving many factors. This thematic review focuses on the extracellular matrix of the skin, in particular its role in wound healing. The authors analyzed the results of fundamental research in recent years, finding promising potential for their transition into real clinical practice.

Keywords: extracellular skin matrix; violation of regeneration; wound healing.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Wound healing stages and main involved components of the extracellular matrix of the skin.
See this image and copyright information in PMC

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