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Review
. 2021 Nov 23;12(12):1850.
doi: 10.3390/genes12121850.

Gene-Environment Interactions in Schizophrenia: A Literature Review

Marah H Wahbeh  1 , Dimitrios Avramopoulos  1
Affiliations
Review

Gene-Environment Interactions in Schizophrenia: A Literature Review

Marah H Wahbeh et al. Genes (Basel). .

Abstract

Schizophrenia is a devastating mental illness with a strong genetic component that is the subject of extensive research. Despite the high heritability, it is well recognized that non-genetic factors such as certain infections, cannabis use, psychosocial stress, childhood adversity, urban environment, and immigrant status also play a role. Whenever genetic and non-genetic factors co-exist, interaction between the two is likely. This means that certain exposures would only be of consequence given a specific genetic makeup. Here, we provide a brief review of studies reporting evidence of such interactions, exploring genes and variants that moderate the effect of the environment to increase risk of developing psychosis. Discovering these interactions is crucial to our understanding of the pathogenesis of complex disorders. It can help in identifying individuals at high risk, in developing individualized treatments and prevention plans, and can influence clinical management.

Keywords: Toxoplasma gondii; cannabis; environment; gene-environment interactions; genetics; polygenic risk score; psychosis; schizophrenia.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Disease G.B.D., Injury I., Prevalence C. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1789–1858. doi: 10.1016/S0140-6736(18)32279-7. - DOI - PMC - PubMed
    1. Roy A. Depression, attempted suicide, and suicide in patients with chronic schizophrenia. Psychiatr. Clin. N. Am. 1986;9:193–206. doi: 10.1016/S0193-953X(18)30644-0. - DOI - PubMed
    1. Jablensky A., Sartorius N., Ernberg G., Anker M., Korten A., Cooper J.E., Day R., Bertelsen A. Schizophrenia: Manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol. Med. Monogr. Suppl. 1992;20:1–97. doi: 10.1017/S0264180100000904. - DOI - PubMed
    1. Avramopoulos D. Recent Advances in the Genetics of Schizophrenia. Mol. Neuropsychiatry. 2018;4:35–51. doi: 10.1159/000488679. - DOI - PMC - PubMed
    1. Stilo S.A., Murray R.M. Non-Genetic Factors in Schizophrenia. Curr. Psychiatry Rep. 2019;21:100. doi: 10.1007/s11920-019-1091-3. - DOI - PMC - PubMed

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