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Review
. 2021 Dec 17;12(12):2004.
doi: 10.3390/genes12122004.

Genetics and Epigenetics in Allergic Rhinitis

Bo Yoon Choi  1 , Munsoo Han  1 , Ji Won Kwak  1 , Tae Hoon Kim  1
Affiliations
Review

Genetics and Epigenetics in Allergic Rhinitis

Bo Yoon Choi et al. Genes (Basel). .

Abstract

The pathogenesis of allergic rhinitis is associated with genetic, environmental, and epigenetic factors. Genotyping of single nucleotide polymorphisms (SNPs) is an advanced technique in the field of molecular genetics that is closely correlated with genome-wide association studies (GWASs) in large population groups with allergic diseases. Many recent studies have paid attention to the role of epigenetics, including alteration of DNA methylation, histone acetylation, and miRNA levels in the pathogenesis of allergic rhinitis. In this review article, genetics and epigenetics of allergic rhinitis, including information regarding functions and significance of previously known and newly-discovered genes, are summarized. Directions for future genetic and epigenetic studies of allergic rhinitis are also proposed.

Keywords: GWAS; allergic rhinitis; allergy; asthma; epigenetics; genetics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Environmental/genetic/epigenetic factors in AR (Figure was created with Biorender.com, accessed on 13 December 2021).
Figure 2
Figure 2
Venn diagram of genes shared between patients AR and asthma.
Figure 3
Figure 3
Directions for future studies.
See this image and copyright information in PMC

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