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Case Reports
. 1987 Feb;26(1):65-8.
doi: 10.2169/internalmedicine1962.26.65.

Chronic idiopathic neutropenia with hypergammaglobulinemia

N Watanabe, M Kobayashi, Y Shigeta, H Hara
Free article
Case Reports

Chronic idiopathic neutropenia with hypergammaglobulinemia

N Watanabe et al. Jpn J Med. 1987 Feb.
Free article

Abstract

Chronic idiopathic neutropenia can occur in spite of the normocellular bone marrow in myeloid series with or without anti-neutrophilic antibody. We report a patient with chronic neutropenia and severe polyclonal hypergammaglobulinemia. The patient demonstrated a positive anti-neutrophil antibody by fluorocytometry, although granulocyte-specific anti-nuclear factor and anti-stem cell (CFU-GM) antibody were negative. Thus, neutropenia of this patient appeared to be due to the antibody-mediated destruction of neutrophils. Both neutropenia and hypergammaglobulinemia were normalized by the administration of prednisone.

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