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Comment
. 2022 Feb;32(2):115-116.
doi: 10.1038/s41422-021-00601-x.

Disinhibitory feedback loops for reward and aversion

Barbara Juarez  1   2   3 , Larry S Zweifel  4   5   6
Affiliations
Comment

Disinhibitory feedback loops for reward and aversion

Barbara Juarez et al. Cell Res. 2022 Feb.
No abstract available

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Figures

Fig. 1
Fig. 1. Disinhibitory loops for reward and aversion.
D1NAc→VM neurons send a GABAergic projection to the VTA where they inhibit GABA-releasing neurons that inhibit dopamine-producing cells, setting up a direct NAc→VTA pathway. This disinhibition by D1NAc→VM neurons is enhanced by D1R activation setting up a positive feedback loop that further boosts dopamine release in the NAc leading to rewarding behavior. Conversely, D1NAc→VP neurons send a GABAergic projection to the VP that inhibits VP-GABA projections to the VM. These VP → VM projections inhibit VTA GABA neurons, setting up an indirect NAc→VP → VTA pathway. Thus, activation of D1NAc→VP neurons inhibits VP → VM projection neurons disinhibiting VTA GABAergic neurons that reduces the activity of VTA dopamine neurons and suppresses dopamine release in the NAc leading to aversive response.
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