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Review
. 2021 Dec 14:2021:4835488.
doi: 10.1155/2021/4835488. eCollection 2021.

A Systematic Review and Meta-Analysis of the Effects of Herbal Medicine Buyang Huanwu Tang in Patients with Poststroke Fatigue

Chul Jin  1 , Seungwon Kwon  1 , Seung-Yeon Cho  1 , Seong-Uk Park  1 , Woo-Sang Jung  1 , Sang-Kwan Moon  1 , Jung-Mi Park  1 , Chang-Nam Ko  1 , Ki-Ho Cho  1
Affiliations
Review

A Systematic Review and Meta-Analysis of the Effects of Herbal Medicine Buyang Huanwu Tang in Patients with Poststroke Fatigue

Chul Jin et al. Evid Based Complement Alternat Med. .

Abstract

Poststroke fatigue (PSF) is reported to occur in 30%-72% of all patients with stroke. PSF not only is a symptom of stroke but has also been reported to adversely affect the prognosis of patients with stroke. However, no treatment has had a significant effect on PSF. In East Asian countries, several herbal medicines have been used to treat stroke, with Buyang Huanwu Tang (BHT) being the most common. This review aimed to evaluate the efficacy and safety of BHT for PSF. A literature search was conducted on MEDLINE, CENTRAL, Scopus, CiNii, CNKI, OASIS, NDSL, and KTKP databases for randomized controlled trials that evaluated the effects and safety of BHT on PSF. Six studies (n = 427) were included. The overall methodological quality of these studies was relatively low. In the adjunctive BHT group, the meta-analysis indicated statistically significant improvements in the Fatigue Severity Scale score (mean difference -1.49, 95% CI [-2.25, -0.73]) and total clinical efficacy rate (risk ratio 0.11, 95% CI [0.03, 0.41]) compared to those in the nonherbal group. Adverse events were only reported in one study, and no serious adverse events occurred. BHT administration might be effective in the treatment of PSF. We were unable to draw definitive conclusions owing to the limitations of the included studies. The trial is registered with CRD42019130178 in PROSPERO.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram of study selection.
Figure 2
Figure 2
(a) Risk of bias graph: review of the authors' judgments regarding each risk of bias item is presented as percentages across all included studies. (b) Risk of bias summary: review of authors' judgments regarding each risk of bias item for each included study. “+”: low risk, “?”: unclear risk, and “−”: high risk.
Figure 3
Figure 3
(a) FSS: Buyang Huanwu Tang + conventional therapies vs. conventional therapies only. (b) FSS: Buyang Huanwu Tang vs. conventional therapies BHT: Buyang Huanwu Tang; CT: conventional therapy; FSS: Fatigue Severity Scale.
See this image and copyright information in PMC

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