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. 2020 Oct 31;13(3):2365.
doi: 10.4022/jafib.2365. eCollection 2020 Oct-Nov.

Quantifying Risk Factors for Atrial Fibrillation: Retrospective Review of a Large Electronic Patient Database

Jaclyn Rivington  1 , Patrick Twohig  2
Affiliations

Quantifying Risk Factors for Atrial Fibrillation: Retrospective Review of a Large Electronic Patient Database

Jaclyn Rivington et al. J Atr Fibrillation. .

Abstract

Background: Despite the numerous comorbidities associated with atrial fibrillation (AF), the relative risk has been varying and not well-documented.

Aim: To quantify the risk of diseases associated with AF.

Methods: Population-based retrospective analysis in IBM Explorys (1999-2019), an electronic database with over 63 million patients in the United States. Odds ratios were calculated between AF and other diseases. AF patients were also stratified by age, gender, and race to assess trends of AF in different demographic groups.

Results: 1,812,620 patients had AF in the database. Congestive heart failure had the highest association with AF (OR 42.95). Cardiomyopathy, coronary artery disease, hypertension, and myocardial infarction all had odds greater than 15. Anemia of chronic disease and chronic kidney disease had odds greater than 18, the highest for chronic inflammatory conditions. Other conditions commonly associated with AF were found to have odds less than 8, including hyperthyroidism, alcohol use, and sleep apnea. Helicobacter pylori infection had the lowest odds at 1.98.

Conclusions: Epidemiologic information could be integrated with current clinical algorithms to more rapidly identify patients at risk of AF.

Keywords: Atrial fibrillation; Congestive heart failure; Epidemiology; Inflammation; Risk factors.

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Figures

Figure 1.
Figure 1.. Forest plots of odds ratios of comorbidities with Atrial Fibrillation.
Figure 2.
Figure 2.. Forest plots of odds ratios of inflammatory conditions with Atrial Fibrillation.
See this image and copyright information in PMC

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