Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar;41(1):211-242.
doi: 10.1007/s10555-021-10002-6. Epub 2021 Dec 24.

Adipocytokines and disease progression in endometrial cancer: a systematic review

Irene Ray  1   2 , Lisiane B Meira  3 , Agnieszka Michael  3   4 , Patricia E Ellis  3   4
Affiliations

Adipocytokines and disease progression in endometrial cancer: a systematic review

Irene Ray et al. Cancer Metastasis Rev. 2022 Mar.

Erratum in

Abstract

The objective of the study was to document the effect of adipocytokines on endometrial cancer progression. A search of the databases CINAHL, Medline, PubMed, Cochrane, Web of Science, Embase and Google Scholar was performed for English language articles from January 2000 to December 2020 using the keywords: (Endometrial cancer) AND (progression OR metastasis) AND (adipocytokine OR adiponectin OR leptin OR visfatin OR IL-6 OR TNF-α OR adipokine OR cytokine). Forty-nine studies on adipocytokines have been included in this review. Adiponectin has been linked with anti-proliferative and anti-metastatic effects on endometrial cancer cells and is associated with a better prognosis. Leptin, visfatin and resistin are linked to the stimulation of endometrial cancer growth, proliferation, invasion and metastasis and are associated with worse prognosis or with a higher grade/stage of endometrial cancer. IL-6, Il-11, IL-31, IL-33, TNF-α, TGF-β1, SDF-1 and CXCR are involved in endometrial cancer cell growth and metastasis or involved in epithelial mesenchymal transformation (EMT) or associated with advanced disease. Adipocytokines have been found to directly impact endometrial cancer cell proliferation, invasion and migration. These molecules and their signalling pathways may be used to determine prognosis and course of the disease and may also be exploited as potential targets for cancer treatment and prevention of progression.

Keywords: Adipocytokines; Adipokines; Cytokines; Disease progression; Endometrial cancer; Systematic review.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Preferred Reporting Items for Systematic Reviews and Meta Analyses Protocols (PRISMA) flow diagram of screened, excluded and analysed publications
Fig. 2
Fig. 2
Data synthesis
See this image and copyright information in PMC

References

    1. Dimitrov T, Gorchev G, Tomov S. Modern concepts of ethiological pathogenesis and treatment of endometrial carcinoma, research literature review. International Journal of Science and Research (IJSR) 2016;5(7):440–445. doi: 10.21275/v5i7.ART2016122. - DOI
    1. Uterine cancer incidence statistics. Cancer Research UK. Accessed Oct 2020, from http://www.cancerresearchuk.org/health-professional/cancer-statistics/st....
    1. Cancer facts and figures 2021. American Cancer Society. Accessed May 2021 from https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts...
    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Erratum in: CA Cancer J Clin. 2020;70(4):313. - PubMed
    1. Argyrakopoulou G, Dalamaga M, Spyrou N, Kokkinos A. Gender differences in obesity-related cancers. Current Obesity Reports. 2021;10(2):100–115. doi: 10.1007/s13679-021-00426-0. - DOI - PubMed

Publication types

LinkOut - more resources