Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr;36(4):e14568.
doi: 10.1111/ctr.14568. Epub 2022 Jan 10.

Insights into early postoperative acute kidney injury following lung transplantation

Mena Botros  1 , Kenneth Jackson  2 , Priyamvada Singh  3 , Justin P Rosenheck  1 , Asvin M Ganapathi  4 , Matthew C Henn  4 , Molly M Howsare  5 , Nahush A Mokadam  4 , Todd Pesavento  3 , Bryan A Whitson  4 , David R Nunley  1 , Brian C Keller  1
Affiliations

Insights into early postoperative acute kidney injury following lung transplantation

Mena Botros et al. Clin Transplant. 2022 Apr.

Abstract

Background: Acute kidney injury (AKI) is a common complication after lung transplantation (LT) and is associated with higher cost and mortality. We sought to evaluate the incidence of postoperative AKI, defined as AKI within 14 days of transplant, and identify associated perioperative factors.

Methods: We conducted a single-center, retrospective review of 153 lung transplant recipients. Postoperative AKI was determined using the RIFLE (Risk, Injury, Failure, Loss, End Stage) criteria. Perioperative covariates and their association with postoperative AKI were analyzed using Cox proportional hazards. Kaplan-Meier survival curves were constructed to evaluate patient survival at 1 year and data finalization. A sub-analysis was performed evaluating factors associated with early AKI (within 48 h of transplant) and late AKI.

Results: Postoperative AKI occurred in 36.6% of patients with 51.8% of cases occurring within 48 h of LT. Recipient race, transplant type, cardiopulmonary support, and red blood cell administration were associated with postoperative AKI. Survival was significantly lower in patients with postoperative AKI following LT.

Conclusions: Postoperative AKI within 2 weeks of lung transplant is associated with lower short- and long-term survival. Perioperative factors associated with postoperative AKI may be potential points of intervention to minimize AKI development in the future.

Keywords: RIFLE; acute kidney injury; lung transplant.

PubMed Disclaimer

References

REFERENCES

    1. Chambers DC, Cherikh WS, Harhay MO, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-sixth adult lung and heart-lung transplantation Report-2019; Focus theme: donor and recipient size match. J Heart Lung Transplant. 2019;38(10):1042-1055.
    1. Sawhney S, Marks A, Fluck N, et al. Post-discharge kidney function is associated with subsequent ten-year renal progression risk among survivors of acute kidney injury. Kidney Int. 2017;92(2):440-452.
    1. Lertjitbanjong P, Thongprayoon C, Cheungpasitporn W, et al. Acute kidney injury after lung transplantation: a systematic review and meta-analysis. J Clin Med. 2019;8(10).
    1. Bennett D, Fossi A, Marchetti L, et al. Postoperative acute kidney injury in lung transplant recipients. Interact Cardiovasc Thorac Surg. 2019;28(6):929-935.
    1. Xue J, Wang L, Chen CM, Chen JY, Sun ZX. Acute kidney injury influences mortality in lung transplantation. Ren Fail. 2014;36(4):541-545.

LinkOut - more resources