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Case Reports
. 2022 Apr:243:208-213.e3.
doi: 10.1016/j.jpeds.2021.12.025. Epub 2021 Dec 22.

mRNA Coronavirus Disease 2019 Vaccine-Associated Myopericarditis in Adolescents: A Survey Study

Utkarsh Kohli  1 , Lavina Desai  2 , Devyani Chowdhury  3 , Ashraf S Harahsheh  4 , Alexandra B Yonts  5 , Annette Ansong  4 , Arash Sabati  6 , Hoang H Nguyen  7 , Tarique Hussain  7 , Danyal Khan  8 , David A Parra  9 , Jennifer A Su  10 , Jyoti K Patel  11 , Christina Ronai  12 , Monique Bohun  12 , Bishara J Freij  13 , Matthew J O'Connor  14 , Joseph W Rosanno  14 , Aamisha Gupta  15 , Arash Salavitabar  16 , Adam L Dorfman  16 , Jesse Hansen  16 , Olivia Frosch  16 , Elizabeth L Profita  17 , Shiraz Maskatia  17 , Deepika Thacker  18 , Shubhika Shrivastava  18 , Tyler H Harris  19 , Brian Feingold  19 , Stuart Berger  20 , Michael Campbell  21 , Salim F Idriss  21 , Srikant Das  22 , Markus S Renno  22 , Ken Knecht  22 , S Yukiko Asaki  23 , Sunil Patel  24 , Ravi Ashwath  25 , Renata Shih  26 , John Phillips  27 , Bibhuti Das  28 , Preeti Ramachandran  29 , Eyal Sagiv  30 , Aarti H Bhat  30 , Jonathan N Johnson  31 , Nathaniel W Taggart  31 , Jason Imundo  32 , Natasha Nakra  33 , Shashank Behere  34 , Anjlee Patel  35 , Avichal Aggarwal  36 , Saif Aljemmali  37 , Sean Lang  38 , Sarosh P Batlivala  38 , Daniel E Forsha  39 , Gregory P Conners  40 , Jana Shaw  40 , Frank C Smith  40 , Linda Pauliks  41 , Joseph Vettukattil  41 , Kenneth Shaffer  42 , Stefanie Cheang  43 , Sonia Voleti  44 , Rajesh Shenoy  45 , Rukmini Komarlu  46 , Shea J Ryan  47 , Christopher Snyder  48 , Neha Bansal  49 , Madhu Sharma  49 , Jeffrey A Robinson  50 , Sandra R Arnold  51 , Christine M Salvatore  52 , Madan Kumar  53 , Michael A Fremed  54 , Julie S Glickstein  54 , Melissa Perrotta  55 , William Orr  56 , Tamika Rozema  57 , Muthayipalayam Thirumoorthi  58 , Charles J Mullett  59 , Jocelyn Y Ang  2
Affiliations
Case Reports

mRNA Coronavirus Disease 2019 Vaccine-Associated Myopericarditis in Adolescents: A Survey Study

Utkarsh Kohli et al. J Pediatr. 2022 Apr.

Abstract

In this survey study of institutions across the US, marked variability in evaluation, treatment, and follow-up of adolescents 12 through 18 years of age with mRNA coronavirus disease 2019 (COVID-19) vaccine-associated myopericarditis was noted. Only one adolescent with life-threatening complications was reported, with no deaths at any of the participating institutions.

Keywords: mRNA COVID-19 vaccine-associated myopericarditis; outcomes; survey; variability.

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Figures

Figure 1
Figure 1
A, Bed capacity of institutions across the 4 geographic regions of the US. ∗One institution located in the Northeast admits to a center in the South. #The difference in bed capacity between the institutions in the Northeast (n = 10, median 141, range 26-500), Midwest (n = 17, median 228, range 20-670), South (n = 21, median 250, range 110-550), and West (n = 9, median 361, range 80-505) was not statistically significant (P = .11). B, Number of adolescents admitted with mRNA COVID-19 VAM vs bed capacity. ∗One institution did not provide data on the number of adolescents treated. #None of the institutions reported treating more than 25 adolescents. ˆNone (median 34, range 20-48), between 1 and 5 (median 200, 26-670), between 6 and 10 (median 289, 48-500), and between 11 and 25 adolescents (median 324 range 80-505). The difference in the bed capacity between the institutions that treated 1-5, 6-10, and 11-25 adolescents was not statistically significant (P = .14).
Figure 2
Figure 2
Estimated number of adolescents with mRNA COVID-19 VAM treated in different geographic regions of the US. ∗Northeast (mean 40, range 20-60), Midwest (mean 95, range 55-135), South (mean 100, range 55-145), and West (mean 91, range 57-125). #The numbers within parentheses indicate the number of institutions in that region. ˆ As of September 9, 2021, the total number of adolescents 12 through 17 years of age vaccinated in the 4 geographic regions is as follows: Northeast: 2 053 241, Midwest: 1 990 101, South: 3 655 317, and West: 2 905 148.
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References

    1. Centers for Disease Control and Prevention (CDC) Myocarditis and Pericarditis After mRNA COVID-19 Vaccination. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/myocarditis.html Accessed September 10, 2021.
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