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Comment
. 2021 Dec 24;6(1):437.
doi: 10.1038/s41392-021-00844-5.

Acquired cancer tyrosine kinase inhibitor resistance: ROS as critical determinants

Sander Bekeschus  1
Affiliations
Comment

Acquired cancer tyrosine kinase inhibitor resistance: ROS as critical determinants

Sander Bekeschus. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1
Cycling persisters upon TKI drug pressure. In unchallenged tumor cells with physiological Nrf2 levels, drug exposure leads to a clonal selection of cells with acquired drug resistance characterized by supraphysiological Nrf2 levels. Only cells with high antioxidant defense levels can proliferation while drug-resistant cells with lower levels do not. Nrf2 and antioxidant defense levels ceased after drug removal, ultimately resembling tumor cells before the initial drug challenge. Hence, drug sensitivity and resistance are dynamic cellular states controlled by a set of antioxidant defense response genes rather than separate entities a priori. Created with BioRender.com
See this image and copyright information in PMC

Comment on

  • Cycling cancer persister cells arise from lineages with distinct programs.
    Oren Y, Tsabar M, Cuoco MS, Amir-Zilberstein L, Cabanos HF, Hütter JC, Hu B, Thakore PI, Tabaka M, Fulco CP, Colgan W, Cuevas BM, Hurvitz SA, Slamon DJ, Deik A, Pierce KA, Clish C, Hata AN, Zaganjor E, Lahav G, Politi K, Brugge JS, Regev A. Oren Y, et al. Nature. 2021 Aug;596(7873):576-582. doi: 10.1038/s41586-021-03796-6. Epub 2021 Aug 11. Nature. 2021. PMID: 34381210 Free PMC article.

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