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Comment
. 2021 Dec 24;6(1):440.
doi: 10.1038/s41392-021-00842-7.

MEOX1: a novel druggable target that orchestrates the activation of fibroblasts in cardiac fibrosis

David Schumacher  1   2 , Fabian Peisker  3 , Rafael Kramann  3   4   5
Affiliations
Comment

MEOX1: a novel druggable target that orchestrates the activation of fibroblasts in cardiac fibrosis

David Schumacher et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
a Schematic step-by-step overview of the mechanisms leading from cardiac injury to activation of pro-fibrotic gene expression in fibroblasts, as depicted by Alexanian et al. Sites of experimental interference used to clarify critical regulatory elements are highlighted. (heart graphic source: smart.servier.com) b Single-cell RNA expression of MEOX1, including 24 different organs of origin. The figure was generated using the single-cell dataset from the tabula sapiens consortium
See this image and copyright information in PMC

Comment on

  • A transcriptional switch governs fibroblast activation in heart disease.
    Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, Andreoletti G, Jain R, McKinsey TA, Rosenfeld MG, Gifford CA, Pollard KS, Haldar SM, Srivastava D. Alexanian M, et al. Nature. 2021 Jul;595(7867):438-443. doi: 10.1038/s41586-021-03674-1. Epub 2021 Jun 23. Nature. 2021. PMID: 34163071 Free PMC article.

References

    1. Alexanian M, et al. A transcriptional switch governs fibroblast activation in heart disease. Nature. 2021;595:438–443. doi: 10.1038/s41586-021-03674-1. - DOI - PMC - PubMed
    1. Henderson NC, Rieder F, Wynn TA. Fibrosis: from mechanisms to medicines. Nature. 2020;587:555–566. doi: 10.1038/s41586-020-2938-9. - DOI - PMC - PubMed
    1. Nicholls SJ, et al. Apabetalone and hospitalization for heart failure in patients following an acute coronary syndrome: a prespecified analysis of the BETonMACE study. Cardiovasc Diabetol. 2021;20:13. doi: 10.1186/s12933-020-01199-x. - DOI - PMC - PubMed
    1. Douville JM, et al. Mechanisms of MEOX1 and MEOX2 regulation of the cyclin-dependent kinase inhibitors p21 and p16 in vascular endothelial cells. PLoS One. 2011;6:e29099. doi: 10.1371/journal.pone.0029099. - DOI - PMC - PubMed
    1. Bushweller JH. Targeting transcription factors in cancer—from undruggable to reality. Nat. Rev. Cancer. 2019;19:611–624. doi: 10.1038/s41568-019-0196-7. - DOI - PMC - PubMed

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