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. 2022 Jul;54(7):964-972.
doi: 10.1016/j.dld.2021.12.002. Epub 2021 Dec 23.

Association of metabolic health phenotypes, obesity, and hepatocellular carcinoma risk

Duaa S Nasereldin  1 , Launia J White  2 , David O Hodge  2 , Lewis R Roberts  3 , Tushar Patel  4 , Samuel O Antwi  5
Affiliations

Association of metabolic health phenotypes, obesity, and hepatocellular carcinoma risk

Duaa S Nasereldin et al. Dig Liver Dis. 2022 Jul.

Abstract

Background: The obesity and hepatocellular carcinoma (HCC) risk association may differ by individuals' metabolic health status.

Aim: To investigate the association between obesity categories and HCC risk among individuals with different metabolic health phenotypes.

Methods: A case-control study among 518 HCC cases and 1,036 frequency-matched controls was conducted. Body mass index (BMI) was assessed before diagnosis. Pre-diagnosis data on dyslipidemia, hypertension, and diabetes were used to categorize participants as metabolically healthy or metabolically unhealthy. Participants were further categorized into metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW), metabolically unhealthy overweight (MUOW), and metabolically unhealthy obese (MHO). We used logistic regression to calculate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs).

Results: Being overweight (OR=1.68, 95%CI=1.21-2.34) or obese (OR=1.49, 95%CI=1.11-1.89) was associated with higher HCC risk. Among metabolically healthy participants, no association was found between being overweight or obese and HCC risk. However, among the metabolically unhealthy participants, being overweight (OR=1.89, 95%CI=1.31-2.72) or obese (OR=1.50, 95%CI=1.07-2.09) was associated with higher HCC risk. Compared to the MHNW phenotype, no association was found between the MHOW and MHO phenotypes and HCC risk, but the MUNW (OR=1.94, 95%CI=1.09-3.43), MUOW (OR=3.78, 95%CI=2.15-6.65), and MUO (OR=2.93, 95%CI=1.70-5.05) phenotypes were associated with higher HCC risk.

Conclusion: The association between BMI and HCC appears to be restricted to individuals with underlying metabolic abnormalities.

Keywords: BMI; HCC; Hepatocellular carcinoma; Liver cancer; Metabolic; obesity.

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Conflict of interest statement

Conflict of interest None declared.

References

    1. Sia D, Villanueva A, Friedman SL, et al. Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis. Gastroenterology 2017;152:745–61. - PMC - PubMed
    1. American Cancer Society. Cancer Facts & Figures 2021. Atlanta: American Cancer Society; 2021.
    1. Giannini EG, Farinati F, Ciccarese F, et al. Prognosis of untreated hepatocellular carcinoma. Hepatology 2015;61:184–90. - PubMed
    1. White DL, Thrift AP, Kanwal F, et al. Incidence of Hepatocellular Carcinoma in All 50 United States, From 2000 Through 2012. Gastroenterology 2017;152:812–20.e5. - PMC - PubMed
    1. Petrick JL, Kelly SP, Altekruse SF, et al. Future of Hepatocellular Carcinoma Incidence in the United States Forecast Through 2030. J Clin Oncol 2016;34:1787–94. - PMC - PubMed

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