Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec 24;18(4):298-303.
doi: 10.4274/tjod.galenos.2021.16132.

The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study

Engin Yıldırım  1 , Can Türkler  2 , Ümit Görkem  3 , Ömer Yavuz Şimşek  4 , Ercan Yılmaz  5 , Hülya Aladağ  1
Affiliations

The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study

Engin Yıldırım et al. Turk J Obstet Gynecol. .

Abstract

Objective: Endometrial hyperplasia (EH) is considered an endometrial cancer precursor. This study aimed to determine the role of oxidative stress and thiol groups with antioxidant properties in EH pathogenesis.

Materials and methods: In our prospective case-control study, participants were washed with 5 mL of saline before the endometrial biopsy. Endometrial washing fluid was taken into microtubules, and thiol and disulfide levels were analyzed using the Ellman reagent.

Results: A total of 108 patients were in the EH group and 84 patients in the control group. The total and native thiol levels were higher values in the control group (p<0.001, for both). Disulfide levels were higher in the EH group (p<0.001). Native/total thiol ratio and disulfide/total thiol ratio were higher in the EH group (p<0.001, for both). The analysis performed in the control group revealed a significant positive correlation between estradiol and disulfide levels (r=0.322, p=0.033). No significant correlation was found between estradiol and disulfide in the EH group.

Conclusion: Oxidative stress level was higher in the washing fluids of patients with EH and this stress plays a role in the EH etiology.

Keywords: Endometrial hyperplasia; disulfide; oxidative stress; thiol.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

References

    1. Fraser IS, Critchley HO, Munro MG, Broder M Writing Group for this Menstrual Agreement Process. A process designed to lead to international agreement on terminologies and definitions used to describe abnormalities of menstrual bleeding. Fertil Steril. 2007;87:466–76. - PubMed
    1. Madhra M, Fraser IS, Munro MG, Critchley HO. Abnormal uterine bleeding: advantages of formal classification to patients, clinicians and researchers. Acta Obstet Gynecol Scand. 2014;93:619–25. - PubMed
    1. Sherman ME. Theories of endometrial carcinogenesis: a multidisciplinaryapproach. Mod Pathol. 2000;13:295–308. - PubMed
    1. Daud S, Jalil SS, Griffin M, Ewies AA. Endometrial hyperplasia- the dilemma of management remains: a retrospective observational study of 280 women. Eur J Obstet Gynecol Reprod Biol. 2011;159:172–5. - PubMed
    1. Khorram O, Lessey BA. Alterations in expression of endometrial endothelial nitric oxide synthase and alpha(v) beta (3) integrin in women with endometriosis. Fertil Steril. 2002;78:860–4. - PubMed

LinkOut - more resources