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Review
. 2022 Apr;34(2):55-68.
doi: 10.1017/neu.2021.47. Epub 2021 Dec 27.

Treatment-induced mood switching in affective disorders

Siu Wa Tang  1   2 , Wayne H Tang  2 , Brian E Leonard  2   3
Affiliations
Review

Treatment-induced mood switching in affective disorders

Siu Wa Tang et al. Acta Neuropsychiatr. 2022 Apr.

Abstract

Many patients under treatment for mood disorders, in particular patients with bipolar mood disorders, experience episodes of mood switching from one state to another. Various hypotheses have been proposed to explain the mechanism of mood switching, spontaneously or induced by drug treatment. Animal models have also been used to test the role of psychotropic drugs in the switching of mood states. We examine the possible relationship between the pharmacology of psychotropic drugs and their reported incidents of induced mood switching, with reference to the various hypotheses of mechanisms of mood switching.

Keywords: affective disorders; antidepressant drugs; bipolar disorder.

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