Effects of Fu Fang Yi Mu Cao capsules combined with Yiqi Xiaoyu decoction on lochia

Abstract

Objective: To investigate the effects of Fu Fang Yi Mu Cao (FFYMC) capsules combined with Yiqi Xiaoyu (YX) decoction on persistent lochia after birth.

Methods: In this retrospective analysis, 120 patients with lochia treated in our hospital from January 2014 to October 2020 were enrolled as study subjects. Sixty of each were randomly allocated into the study group (60 cases, treated with FFYMC capsules and YX decoction) and the control group (60 cases, treated with YX decoction). The two groups were compared in terms of efficacy, volume of lochia and changes in Traditional Chinese Medicine Syndrome Score (TCMSS) before and after intervention, and the incidence of adverse reactions.

Results: (1) The total effective rate in the study group was 100.00%, which was significantly higher than that in the control group (P<0.05); (2) The difference in volume of lochia between two groups before the intervention was not statistically significant (P>0.05), and was significantly lower in the study group than in the control group at day 4 and day 7 of the intervention (P<0.05); (3) The difference in TCMSS between two groups before the treatment was not statistically significant (P>0.05). TCMSS was lower in the study group than in the control group after treatment (P<0.05); (4) The decreased height of uterine fundus in the study group was higher than that in the control group at 5 d after treatment (P<0.05); (5) The plasma viscosity in the study group was significantly lower than that in the control group (P<0.05); (6) The total incidence of adverse reactions in the study group was 8.33%, which was not significantly different from the control group which was 11.67% (P>0.05).

Conclusion: FFYMC capsule and YX decoction could improve the treatment effect for primiparas with lochia in terms of reducing volume of lochia and improving clinical symptoms with high safety.

Keywords: Fu Fang Yi Mu Cao capsules; Yiqi Xiaoyu decoction; clinical study; lochia.

Figure 1

Comparison of volume of lochia between two groups. The difference between the two groups in terms of volume of lochia was not statistically significant (P>0.05) before intervention, and volume of lochia was significantly lower in the study group than in the control group at both day 4 and day 7 of the intervention (P<0.05). #represents statistically significant difference between groups of the same index.

Figure 2

Comparison of maternal TCMSS before and after intervention between two groups. The difference between two groups in terms of TCMSS before intervention was not significant (P>0.05) (A). After intervention, the scores were lower in the study group than in the control group (P<0.05) (B). TCMSS before and after intervention differed significantly between study group (C) and control group (D) (P<0.05).

Figure 3

Comparison of decreased height of uterine fundus between two groups. There was no significant difference in the decreased height of uterine fundus between the study group and the control group at day 1 and day 3 after treatment (P>0.05). At day 5 after treatment, the decreased height of uterine fundus in the study group was significantly higher than that in the control group, and the difference between groups was statistically significant (P<0.05). #represents statistically significant difference between groups of the same index.

Figure 4

Comparison of hemorheological indices before and after the intervention between two groups. After treatment, the plasma viscosity of the study group (A) was significantly lower than that of the control group (P<0.05), while there was no statistically significant difference between the groups in erythrocyte sedimentation rate (B) (P>0.05). #represents statistically significant difference between groups of the same index.