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Comment
. 2021;12(Suppl 6):316.
Epub 2021 Sep 20.

Commentary on NNT Mediates Redox-Dependent Pigmentation via a UVB-And MITF-Independent Mechanism

Jennifer Allouche  1 , Inbal Rachmin  1 , David E Fisher  1   2 , Elisabeth Roider  1   2   3   4
Affiliations
Comment

Commentary on NNT Mediates Redox-Dependent Pigmentation via a UVB-And MITF-Independent Mechanism

Jennifer Allouche et al. J Cell Sci Ther. 2021.
No abstract available

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Conflict of interest statement

DISCLOSURE D.E.F. has a financial interest in Soltego, a company developing salt inducible kinase inhibitors for topical skin-darkening treatments that might be used for a broad set of human applications. The interests of D.E.F. were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict-of-interest policies.

Figures

Figure 1:
Figure 1:
Skin pigmentation mechanisms.
See this image and copyright information in PMC

Comment on

  • NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.
    Allouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, McConnell AM, Kato S, Fan S, Kawakami A, Suita Y, Wakamatsu K, Igras V, Zhang J, Navarro PP, Lugo CM, Noonan HR, Christie KA, Itin K, Mujahid N, Lo JA, Won CH, Evans CL, Weng QY, Wang H, Osseiran S, Lovas A, Németh I, Cozzio A, Navarini AA, Hsiao JJ, Nguyen N, Kemény LV, Iliopoulos O, Berking C, Ruzicka T, Gonzalez-José R, Bortolini MC, Canizales-Quinteros S, Acuna-Alonso V, Gallo C, Poletti G, Bedoya G, Rothhammer F, Ito S, Schiaffino MV, Chao LH, Kleinstiver BP, Tishkoff S, Zon LI, Nijsten T, Ruiz-Linares A, Fisher DE, Roider E. Allouche J, et al. Cell. 2021 Aug 5;184(16):4268-4283.e20. doi: 10.1016/j.cell.2021.06.022. Epub 2021 Jul 6. Cell. 2021. PMID: 34233163 Free PMC article.

References

    1. Rachmin I, Ostrowski SM, Weng QY, Fisher DE. Topical treatment strategies to manipulate human skin pigmentation. Adv Drug Deliv Rev. 2020; 153:65–71. - PMC - PubMed
    1. Allouche J, Rachmin I, Adhikari K, Suita Y, Zhang J, Cozzio A, et al. NNT mediates redox-dependent pigmentation via a UVB-and MITF-independent mechanism. Cell. 2021; 184:4268–4283. - PMC - PubMed
    1. Yin F, Sancheti H, Cadenas E. Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells. Biochim Biophys Acta. 2012; 1817:401–9. - PMC - PubMed
    1. Allouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, Connell Mc et al. NNT Mediates Redox-Dependent Pigmentation via a UVB and MITF Independent Mechanism. Cell. 2021; 00757: S0092–8674. - PMC - PubMed
    1. Yin F, Sancheti H, Cadenas E. Silencing of Nicotinamide Nucleotide Transhydrogenase Impairs Cellular Redox Homeostasis and Energy Metabolism in PC12 Cells. Biochim Biophys Acta 2012; 1817: 401–409. - PMC - PubMed

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