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Review
. 2021 Dec 10:9:767510.
doi: 10.3389/fcell.2021.767510. eCollection 2021.

Metabolic Reprogramming and Cell Adhesion in Acute Leukemia Adaptation to the CNS Niche

Nitesh D Sharma  1   2 , Esra'a Keewan  1   2 , Ksenia Matlawska-Wasowska  1   2
Affiliations
Review

Metabolic Reprogramming and Cell Adhesion in Acute Leukemia Adaptation to the CNS Niche

Nitesh D Sharma et al. Front Cell Dev Biol. .

Abstract

Involvement of the Central Nervous System (CNS) in acute leukemia confers poor prognosis and lower overall survival. Existing CNS-directed therapies are associated with a significant risk of short- or long-term toxicities. Leukemic cells can metabolically adapt and survive in the microenvironment of the CNS. The supporting role of the CNS microenvironment in leukemia progression and dissemination has not received sufficient attention. Understanding the mechanism by which leukemic cells survive in the nutrient-poor and oxygen-deprived CNS microenvironment will lead to the development of more specific and less toxic therapies. Here, we review the current literature regarding the roles of metabolic reprogramming in leukemic cell adhesion and survival in the CNS.

Keywords: CNS; acute lymphoblastic leukemia; acute myeloid leukemia; cell adhesion; central nervous system; meninges; metabolism.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
A schematic illustration of metabolic reprogramming and adhesion pathways involved in the central nervous system (CNS) niche in acute leukemia. (A) Leukemic cells can adapt to nutrient-poor and oxygen-deprived CNS by modulating the expression of metabolic and hypoxia-associated genes. (B) Upregulation of adhesion molecules may facilitate leukemic cell infiltration and survival in the CNS microenvironment.
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