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Review
. 2021 Dec 15:2021:4224816.
doi: 10.1155/2021/4224816. eCollection 2021.

Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literature-Based Undivided Perspective

Muhammad Torequl Islam  1 , Cristina Quispe  2 , Jesús Herrera-Bravo  3   4 , Chandan Sarkar  1 , Rohit Sharma  5 , Neha Garg  6 , Larry Ibarra Fredes  7 , Miquel Martorell  8   9 , Mohammed M Alshehri  10 , Javad Sharifi-Rad  11 , Sevgi Durna Daştan  12   13 , Daniela Calina  14 , Radi Alsafi  15 , Saad Alghamdi  15 , Gaber El-Saber Batiha  16 , Natália Cruz-Martins  17   18   19
Affiliations
Review

Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literature-Based Undivided Perspective

Muhammad Torequl Islam et al. Biomed Res Int. .

Abstract

Dengue remains one of the most serious and widespread mosquito-borne viral infections in human beings, with serious health problems or even death. About 50 to 100 million people are newly infected annually, with almost 2.5 billion people living at risk and resulting in 20,000 deaths. Dengue virus infection is especially transmitted through bites of Aedes mosquitos, hugely spread in tropical and subtropical environments, mostly found in urban and semiurban areas. Unfortunately, there is no particular therapeutic approach, but prevention, adequate consciousness, detection at earlier stage of viral infection, and appropriate medical care can lower the fatality rates. This review offers a comprehensive view of production, transmission, pathogenesis, and control measures of the dengue virus and its vectors.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Diagram with dengue virus and its four serotypes.
Figure 2
Figure 2
Aedes mosquitoes (dengue virus vectors).
Figure 3
Figure 3
Geographical distribution of dengue worldwide.
Figure 4
Figure 4
Mosquito life cycle.
Figure 5
Figure 5
DENV transmission mode between the vector and hosts.
Figure 6
Figure 6
Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus.
Figure 7
Figure 7
Chemical structures of natural compounds acting against dengue.
See this image and copyright information in PMC

References

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