Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022:56:169-184.
doi: 10.1007/7854_2021_278.

The Potential of Psychedelics for End of Life and Palliative Care

Affiliations
Review

The Potential of Psychedelics for End of Life and Palliative Care

David B Yaden et al. Curr Top Behav Neurosci. 2022.

Abstract

End of life and palliative care has improved in recent decades but the psychopharmacological options available to clinicians and patients in these contexts remain limited. In particular, psychological factors such as depression, existential distress, and well-being remain challenging to address with current medications. Here, we review recent research on the use of psychedelics in clinical settings with a particular focus on patients with life-threatening diagnoses. We propose that psychedelics may provide clinicians with an additional psychopharmacological treatment in the context of end of life and palliative care.

Keywords: End of Life; Palliative care; Psilocybin; Psychedelics; Psychiatry.

PubMed Disclaimer

References

    1. Agin-Liebes GI, Malone T, Yalch MM, Mennenga SE, Ponté KL, Guss J, Bossis AP, Grigsby J, Fischer S, Ross S (2020) Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer. J Psychopharmacol 34(2):155–166 - PubMed - DOI
    1. Anderson BT, Danforth A, Daroff R, Stauffer C, Ekman E, Agin-Liebes G et al (2020) Psilocybin-assisted group therapy for demoralized older long-term AIDS survivor men: an open-label safety and feasibility pilot study. EClinicalMedicine 27:100538 - PubMed - PMC - DOI
    1. Aziz NM, Grady PA, Curtis JR (2013) Training and career development in palliative care and end-of-life research: opportunities for development in the US. J Pain Symptom Manage 46(6):938–946 - PubMed - DOI
    1. Barrett FS, Carbonaro TM, Hurwitz E, Johnson MW, Griffiths RR (2018) Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: effects on cognition. Psychopharmacology (Berl) 235(10):2915–2927 - DOI
    1. Barrett FS, Johnson MW, Griffiths RR (2015) Validation of the revised mystical experience questionnaire in experimental sessions with psilocybin. J Psychopharmacol 29(11):1182–1190 - PubMed - PMC - DOI

LinkOut - more resources