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. 2022 May;52(5):835-837.
doi: 10.1002/eji.202149367. Epub 2022 Jan 17.

Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon-, TNF-, and IL-18-dependent manner

Nicholas M Provine  1 , Ali Amini  1 , Lucy C Garner  1 , Michael E B FitzPatrick  1 , Christina Dold  2   3 , Laura Silva Reyes  2   3 , Senthil Chinnakannan  4 , Blanche Oguti  2   3 , Meriel Raymond  2   3 , Fulvia Troise  5   6 , Stefania Capone  7 , Antonella Folgori  7 , Eleanor Barnes  1   4 , Christine S Rollier  2   3 , Andrew J Pollard  2   3 , Paul Klenerman  1   4
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Free article

Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon-, TNF-, and IL-18-dependent manner

Nicholas M Provine et al. Eur J Immunol. 2022 May.
Free article

Abstract

Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18-, TNF-, and type I interferon-dependent manner. This stimulatory capacity was associated with adenovirus vectors of non-species C origin, including the ChAdOx1 vaccine platform.

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References

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