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Editorial
. 2022 Mar;27(3):675-677.
doi: 10.1016/j.drudis.2021.12.020. Epub 2021 Dec 25.

Regulating NETosis: An emerging facet of statin pleiotropy

Shabnam Radbakhsh  1 , Petri T Kovanen  2 , Amirhossein Sahebkar  3
Affiliations
Editorial

Regulating NETosis: An emerging facet of statin pleiotropy

Shabnam Radbakhsh et al. Drug Discov Today. 2022 Mar.

Abstract

NETosis has emerged as a new player in the pathogenesis of several diseases including atherosclerotic cardiovascular disease. There is accumulating evidence suggesting that NETosis is regulated by statins, thereby justifying an important lipid-independent pleiotropic action of statin drugs in reducing the risk of atherothrombosis as well as other pathologies.

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