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Randomized Controlled Trial
. 2021 Nov 25;13(12):4226.
doi: 10.3390/nu13124226.

Effect of Vitamin E Supplement on Bone Turnover Markers in Postmenopausal Osteopenic Women: A Double-Blind, Randomized, Placebo-Controlled Trial

Sakda Arj-Ong Vallibhakara  1   2 , Katanyuta Nakpalat  3 , Areepan Sophonsritsuk  4 , Chananya Tantitham  4 , Orawin Vallibhakara  4
Affiliations
Randomized Controlled Trial

Effect of Vitamin E Supplement on Bone Turnover Markers in Postmenopausal Osteopenic Women: A Double-Blind, Randomized, Placebo-Controlled Trial

Sakda Arj-Ong Vallibhakara et al. Nutrients. .

Abstract

Vitamin E is a strong anti-oxidative stress agent that affects the bone remodeling process. This study evaluates the effect of mixed-tocopherol supplements on bone remodeling in postmenopausal osteopenic women. A double-blinded, randomized, placebo-controlled trial study was designed to measure the effect of mixed-tocopherol on the bone turnover marker after 12 weeks of supplementation. All 52 osteopenic postmenopausal women were enrolled and allocated into two groups. The intervention group received mixed-tocopherol 400 IU/day, while the control group received placebo tablets. Fifty-two participants completed 12 weeks of follow-up. Under an intention-to-treat analysis, vitamin E produced a significant difference in the mean bone resorption marker (serum C-terminal telopeptide of type I collagen (CTX)) compared with the placebo group (-0.003 ± 0.09 and 0.121 ± 0.15, respectively (p < 0.001)). In the placebo group, the CTX had increased by 35.3% at 12 weeks of supplementation versus baseline (p < 0.001), while, in the vitamin E group, there was no significant change of bone resorption marker (p < 0.898). In conclusion, vitamin E (mixed-tocopherol) supplementation in postmenopausal osteopenic women may have a preventive effect on bone loss through anti-resorptive activity.

Keywords: bone health; bone marker turnover; bone turnover; osteopenia; postmenopausal women; tocopherol; vitamin E.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Protocol flow diagram according to CONSORT flow diagram 2010.
Figure 2
Figure 2
The box-plot represents the changed of bone resorption marker. CTX, C-terminal telopeptide of type I collagen.
See this image and copyright information in PMC

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