Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec 18;13(12):4542.
doi: 10.3390/nu13124542.

A Fermented Milk Product Containing B. lactis CNCM I-2494 Improves the Tolerance of a Plant-Based Diet in Patients with Disorders of Gut-Brain Interactions

Boris Le Nevé  1 , Adrian Martinez-De la Torre  2   3   4 , Julien Tap  1 , Adoración Nieto Ruiz  2   3   4 , Muriel Derrien  1 , Aurélie Cotillard  1 , Jean-Michel Faurie  1 , Elizabeth Barba  2   3   4   5 , Marianela Mego  2   3   4 , Quentin Dornic  1 , John Butler  6 , Xavi Merino  2   3   4 , Beatriz Lobo  2   3   4 , Ferran Pinsach Batet  2   3   4 , Marta Pozuelo  2   3   4 , Javier Santos  2   3   4 , Francisco Guarner  2   3   4 , Chaysavanh Manichanh  2   3   4 , Fernando Azpiroz  2   3   4
Affiliations

A Fermented Milk Product Containing B. lactis CNCM I-2494 Improves the Tolerance of a Plant-Based Diet in Patients with Disorders of Gut-Brain Interactions

Boris Le Nevé et al. Nutrients. .

Abstract

Healthy, plant-based diets, rich in fermentable residues, may induce gas-related symptoms. The aim of this exploratory study was to assess the effects of a fermented milk product, containing probiotics, on the tolerance of a healthy diet in patients with disorders of gut-brain interactions (DGBI), complaining of excessive flatulence. In an open design, a 3-day healthy, mostly plant-based diet was administered to patients with DGBI (52 included, 43 completed) before and at the end of 28 days of consumption of a fermented milk product (FMP) containing Bifidobacterium animalis subsp. lactis CNCM I-2494 and lactic acid bacteria. As compared to a habitual diet, the flatulogenic diet increased the perception of digestive symptoms (flatulence score 7.1 ± 1.6 vs. 5.8 ± 1.9; p < 0.05) and the daily number of anal gas evacuations (22.4 ± 12.5 vs. 16.5 ± 10.2; p < 0.0001). FMP consumption reduced the flatulence sensation score (by -1.6 ± 2.2; p < 0.05) and the daily number of anal gas evacuations (by -5.3 ± 8.2; p < 0.0001). FMP consumption did not significantly alter the overall gut microbiota composition, but some changes in the microbiota correlated with the observed clinical improvement. The consumption of a product containing B. lactis CNCM I-2494 improved the tolerance of a healthy diet in patients with DGBI, and this effect may be mediated, in part, by the metabolic activity of the microbiota.

Keywords: B. lactis DN-173010; digestive symptoms; disorders of gut–brain interactions; fermentable carbohydrates; flatulence; microbiota; probiotics.

PubMed Disclaimer

Conflict of interest statement

B.L.N., J.T., M.D., J.M.F., A.C. and Q.D. are Danone Nutricia Research employees. F.A. has received unrestricted research grants from Danone Nutricia Research. Other authors have nothing to disclose.

Figures

Figure 1
Figure 1
Study design. FMP: fermented milk product. Abdominal MRI scheduled in half of the participants.
Figure 2
Figure 2
Flow-chart. FAS 1: full analysis set 1; FAS 2: full analysis set 2.
Figure 3
Figure 3
Effect of consumption of fermented milk product (FMP) on tolerance of a plant-based diet. Data are means [95% confidence interval]. Statistical comparisons were performed by Wilcoxon signed-rank test in each subject using the average of the last 2 days of evaluation periods (on the plant-based diet) before (days 17 and 18) and during FMP consumption (days 45 and 46: n = 43).
Figure 4
Figure 4
Spearman correlation between changes in clinical parameters and bacterial genera. (A). Number of anal gas evacuations. (B). Sensation of flatulence. Strength and significance of Spearman correlations (rho coefficient) are indicated in the colour shade. Red: change in microbiota genera negatively associated with the change in clinical parameter. Blue: change in microbiota genera positively associated with the change in clinical parameter. Only the highest correlations are shown.
Figure 4
Figure 4
Spearman correlation between changes in clinical parameters and bacterial genera. (A). Number of anal gas evacuations. (B). Sensation of flatulence. Strength and significance of Spearman correlations (rho coefficient) are indicated in the colour shade. Red: change in microbiota genera negatively associated with the change in clinical parameter. Blue: change in microbiota genera positively associated with the change in clinical parameter. Only the highest correlations are shown.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Guyonnet D., Schlumberger A., Mhamdi L., Jakob S., Chassany O. Fermented milk containing bifidobacterium lactis dn-173 010 improves gastrointestinal well-being and digestive symptoms in women reporting minor digestive symptoms: A randomised, double-blind, parallel, controlled study. Br. J. Nutr. 2009;102:1654–1662. doi: 10.1017/S0007114509990882. - DOI - PubMed
    1. Guyonnet D., Woodcock A., Stefani B., Trevisan C., Hall C. Fermented milk containing bifidobacterium lactis dn-173 010 improved self-reported digestive comfort amongst a general population of adults. A randomized, open-label, controlled, pilot study. J. Dig. Dis. 2009;10:61–70. doi: 10.1111/j.1751-2980.2008.00366.x. - DOI - PubMed
    1. Marteau P., Guyonnet D., Lafaye de Micheaux P., Gelu S. A randomized, double-blind, controlled study and pooled analysis of two identical trials of fermented milk containing probiotic bifidobacterium lactis cncm i-2494 in healthy women reporting minor digestive symptoms. Neurogastroenterol. Motil. 2013;25:331-e252. doi: 10.1111/nmo.12078. - DOI - PubMed
    1. Marteau P., Le Neve B., Quinquis L., Pichon C., Whorwell P.J., Guyonnet D. Consumption of a fermented milk product containing bifidobacterium lactis cncm i-2494 in women complaining of minor digestive symptoms: Rapid response which is independent of dietary fibre intake or physical activity. Nutrients. 2019;11:92. doi: 10.3390/nu11010092. - DOI - PMC - PubMed
    1. Agrawal A., Houghton L.A., Morris J., Reilly B., Guyonnet D., Goupil Feuillerat N., Schlumberger A., Jakob S., Whorwell P.J. Clinical trial: The effects of a fermented milk product containing bifidobacterium lactis dn-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Aliment. Pharmacol. Ther. 2009;29:104–114. doi: 10.1111/j.1365-2036.2008.03853.x. - DOI - PubMed