Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec 10;13(12):2478.
doi: 10.3390/v13122478.

Immunopathology of RSV: An Updated Review

Harrison C Bergeron  1 , Ralph A Tripp  1
Affiliations
Review

Immunopathology of RSV: An Updated Review

Harrison C Bergeron et al. Viruses. .

Abstract

RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus-host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.

Keywords: RSV; host–pathogen interaction; immunity; immunopathology; respiratory syncytial virus.

PubMed Disclaimer

Conflict of interest statement

Authors have no conflict of interests to declare.

References

    1. Collins P.L., Fearns R., Graham B.S. Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease. Curr. Top. Microbiol. Immunol. 2013;372:3–38. doi: 10.1007/978-3-642-38919-1_1. - DOI - PMC - PubMed
    1. Fearns R., Deval J. New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase. Antivir. Res. 2016;134:63–76. doi: 10.1016/j.antiviral.2016.08.006. - DOI - PubMed
    1. Ke Z., Dillard R.S., Chirkova T., Leon F., Stobart C.C., Hampton C.M., Strauss J.D., Rajan D., Rostad C.A., Taylor J.V., et al. The Morphology and Assembly of Respiratory Syncytial Virus Revealed by Cryo-Electron Tomography. Viruses. 2018;10:446. doi: 10.3390/v10080446. - DOI - PMC - PubMed
    1. Anderson L.J., Hierholzer J.C., Tsou C., Hendry R.M., Fernie B.F., Stone Y., McIntosh K. Antigenic Characterization of Respiratory Syncytial Virus Strains with Monoclonal Antibodies. J. Infect. Dis. 1985;151:626–633. doi: 10.1093/infdis/151.4.626. - DOI - PubMed
    1. Choi Y., Mason C.S., Jones L.P., Crabtree J., Jorquera P.A., Tripp R.A. Antibodies to the Central Conserved Region of Respiratory Syncytial Virus (RSV) G Protein Block RSV G Protein CX3C-CX3CR1 Binding and Cross-Neutralize RSV A and B Strains. Viral Immunol. 2012;25:193–203. doi: 10.1089/vim.2011.0094. - DOI - PMC - PubMed

Publication types

MeSH terms

Substances