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Review
. 2022 Apr 1;50(2):89-96.
doi: 10.1249/JES.0000000000000278.

Physical Exercise and Liver Autophagy: Potential Roles of IL-6 and Irisin

Ana P Pinto  1 , Eduardo R Ropelle  2 , Joe Quadrilatero  3 , Adelino S R da Silva
Affiliations
Review

Physical Exercise and Liver Autophagy: Potential Roles of IL-6 and Irisin

Ana P Pinto et al. Exerc Sport Sci Rev. .

Abstract

Autophagic dysregulation contributes to liver diseases. Although some investigations have examined the effects of endurance and resistance exercise on autophagy activation, potential myokines responsible for skeletal muscle-liver crosstalk are still unknown. Based on experimental studies and bioinformatics, we hypothesized that interleukin 6 (IL-6) and irisin might be key players in the contraction-induced release of molecules that regulate liver autophagic responses.

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