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Review
. 2022 Apr 1;50(2):89-96.
doi: 10.1249/JES.0000000000000278.

Physical Exercise and Liver Autophagy: Potential Roles of IL-6 and Irisin

Affiliations
Review

Physical Exercise and Liver Autophagy: Potential Roles of IL-6 and Irisin

Ana P Pinto et al. Exerc Sport Sci Rev. .

Abstract

Autophagic dysregulation contributes to liver diseases. Although some investigations have examined the effects of endurance and resistance exercise on autophagy activation, potential myokines responsible for skeletal muscle-liver crosstalk are still unknown. Based on experimental studies and bioinformatics, we hypothesized that interleukin 6 (IL-6) and irisin might be key players in the contraction-induced release of molecules that regulate liver autophagic responses.

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References

    1. Rui L. Energy metabolism in the liver. Compr. Physiol . 2014; 4(1):177–97.
    1. Adeva-Andany MM, Pérez-Felpete N, Fernández-Fernández C, Donapetry-García C, Pazos-García C. Liver glucose metabolism in humans. Biosci. Rep . 2016; 36(6):e00416.
    1. Madrigal-Matute J, Cuervo AM. Regulation of liver metabolism by autophagy. Gastroenterology . 2016; 150(2):328–39.
    1. Ueno T, Komatsu M. Autophagy in the liver: functions in health and disease. Nat. Rev. Gastroenterol. Hepatol . 2017; 14(3):170–84.
    1. Tam BT, Siu PM. Autophagic cellular responses to physical exercise in skeletal muscle. Sports Med . 2014; 44(5):625–40.

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