H3.3 safeguards haematopoietic ERV-quilibrium

Nadia Omega Cipta^{1

2}, Ying Chen^{1

3}, Yuin-Han Loh^{4

5

6

7}

Affiliations

¹ Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, Singapore.
² Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
³ NUS Graduate School for Integrative Sciences and Engineering Programme, National University of Singapore, Singapore, Singapore.
⁴ Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, Singapore. yhloh@imcb.a-star.edu.sg.
⁵ Department of Biological Sciences, National University of Singapore, Singapore, Singapore. yhloh@imcb.a-star.edu.sg.
⁶ NUS Graduate School for Integrative Sciences and Engineering Programme, National University of Singapore, Singapore, Singapore. yhloh@imcb.a-star.edu.sg.
⁷ Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. yhloh@imcb.a-star.edu.sg.

Comment

Nadia Omega Cipta et al. Nat Cell Biol. 2022 Jan.

. 2022 Jan;24(1):7-9.

doi: 10.1038/s41556-021-00758-y.

Nadia Omega Cipta^{1

2}, Ying Chen^{1

3}, Yuin-Han Loh^{4

5

6

7}

¹ Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, Singapore.
² Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
³ NUS Graduate School for Integrative Sciences and Engineering Programme, National University of Singapore, Singapore, Singapore.
⁴ Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, Singapore. yhloh@imcb.a-star.edu.sg.
⁵ Department of Biological Sciences, National University of Singapore, Singapore, Singapore. yhloh@imcb.a-star.edu.sg.
⁶ NUS Graduate School for Integrative Sciences and Engineering Programme, National University of Singapore, Singapore, Singapore. yhloh@imcb.a-star.edu.sg.
⁷ Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. yhloh@imcb.a-star.edu.sg.

No abstract available

Comment on

Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation.
Gerber JP, Russ J, Chandrasekar V, Offermann N, Lee HM, Spear S, Guzzi N, Maida S, Pattabiraman S, Zhang R, Kayvanjoo AH, Datta P, Kasturiarachchi J, Sposito T, Izotova N, Händler K, Adams PD, Marafioti T, Enver T, Wenzel J, Beyer M, Mass E, Bellodi C, Schultze JL, Capasso M, Nimmo R, Salomoni P. Gerber JP, et al. Nat Cell Biol. 2021 Dec;23(12):1224-1239. doi: 10.1038/s41556-021-00774-y. Epub 2021 Dec 7. Nat Cell Biol. 2021. PMID: 34876685 Free PMC article.
Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability.
Guo P, Liu Y, Geng F, Daman AW, Liu X, Zhong L, Ravishankar A, Lis R, Barcia Durán JG, Itkin T, Tang F, Zhang T, Xiang J, Shido K, Ding BS, Wen D, Josefowicz SZ, Rafii S. Guo P, et al. Nat Cell Biol. 2022 Jan;24(1):99-111. doi: 10.1038/s41556-021-00795-7. Epub 2021 Dec 27. Nat Cell Biol. 2022. PMID: 34961794 Free PMC article.

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