Native E. coli asparaginase upfront should be replaced by PEGasparaginase upfront in the treatment of pediatric patients with acute lymphoblastic leukemia
- PMID: 34961954
- DOI: 10.1002/hon.2960
Native E. coli asparaginase upfront should be replaced by PEGasparaginase upfront in the treatment of pediatric patients with acute lymphoblastic leukemia
Keywords: Erwinia asparaginase; PEGasparaginase; albumin; allergy; ammonia; asparaginase activity levels; pediatric acute lymphoblastic leukemia; pharmacokinetics; triglyceride.
Comment on
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Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge.J Clin Oncol. 2019 Aug 10;37(23):2051-2061. doi: 10.1200/JCO.18.02439. Epub 2019 Jun 12. J Clin Oncol. 2019. PMID: 31188727 Free PMC article.
References
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- Rizzari C, Lanvers-Kaminsky C, Valsecchi MG, et al. Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study. Haematologica. 2019;104(9):1812-1821.
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- Kloos RQH, Pieters R, Jumelet FMV, de Groot-Kruseman HA, van den Bos C, van der Sluis IM. Individualized asparaginase dosing in childhood acute lymphoblastic leukemia. J Clin Oncol. 2020;38(7):715-724.
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- Vrooman LM, Blonquist TM, Stevenson KE, et al. Efficacy and toxicity of pegaspargase and calaspargase pegol in childhood acute lymphoblastic leukemia: results of DFCI 11-001. J Clin Oncol. 2021:Jco2003692.
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