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. 2021 Nov;501(1):192-196.
doi: 10.1134/S0012496621060028. Epub 2021 Dec 28.

New Morphofunctional Criteria for Resistance Profile in Post-Traumatic Stress Disorder Models as Adrenal Dysfunction Trigger

M V Kondashevskaya  1 , M V Komel'kova  2   3 , V E Tseilikman  2 , O B Tseilikman  2   3 , K A Artem'yeva  4 , V V Aleksankina  4 , M N Boltovskaya  4 , A P Sarapul'tsev  2   5 , P N Popkov  6 , M V Chereshneva  5 , V A Chereshnev  5
Affiliations

New Morphofunctional Criteria for Resistance Profile in Post-Traumatic Stress Disorder Models as Adrenal Dysfunction Trigger

M V Kondashevskaya et al. Dokl Biol Sci. 2021 Nov.

Abstract

For the first time in modeling posttraumatic stress disorder (PTSD), we have described the morphofunctional state of adrenal glands in Wistar rats resistant and sensitive to predator stress (rodent fear of the predator). Despite the evident signs of adrenal dysfunction in both phenotypes, we have discovered the thickening of undifferentiated cell zone and high indices of functional activity of stem cells in resistant animals, suggesting ample adaptation. The most important data demonstrate the direct relationship between the reduction of corticosterone and testosterone levels and adrenal dysfunction in PTSD models. The study results allow considering the adrenal stem cells as potential therapeutic targets.

Keywords: Wistar rats; adrenal stem cells; morphofunctional characteristics of the adrenal glands; post-traumatic stress disorder; stress resistance.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

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