De-risking Clinical Trials: The BIAL Phase I Trial in Foresight

Adam F Cohen^{1

2}, Jeroen van Smeden^{2

3

4}, David J Webb⁵

Affiliations

¹ DDCD Consulting, Leiden, The Netherlands.
² Leiden University Medical Center, Leiden, The Netherlands.
³ Leiden Academic Centre for Drug Research, University of Leiden, Leiden, The Netherlands.
⁴ Centre for Human Drug Research, Leiden, The Netherlands.
⁵ Pharmacology, Toxicology and Therapeutics, Centre for Cardiovascular Science, The University of Edinburgh, Scotland, UK.

Comment

Adam F Cohen et al. Clin Pharmacol Ther. 2022 Feb.

. 2022 Feb;111(2):362-365.

doi: 10.1002/cpt.2498. Epub 2021 Dec 28.

Adam F Cohen^{1

2}, Jeroen van Smeden^{2

3

4}, David J Webb⁵

¹ DDCD Consulting, Leiden, The Netherlands.
² Leiden University Medical Center, Leiden, The Netherlands.
³ Leiden Academic Centre for Drug Research, University of Leiden, Leiden, The Netherlands.
⁴ Centre for Human Drug Research, Leiden, The Netherlands.
⁵ Pharmacology, Toxicology and Therapeutics, Centre for Cardiovascular Science, The University of Edinburgh, Scotland, UK.

No abstract available

Conflict of interest statement

The authors declared no competing interests for this work.

Safety, Tolerability, and Pharmacokinetics of FAAH Inhibitor BIA 10-2474: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Volunteers.
Rocha JF, Santos A, Gama H, Moser P, Falcão A, Pressman P, Wallace Hayes A, Soares-da-Silva P. Rocha JF, et al. Clin Pharmacol Ther. 2022 Feb;111(2):391-403. doi: 10.1002/cpt.2290. Epub 2021 Jun 24. Clin Pharmacol Ther. 2022. PMID: 33998672 Free PMC article. Clinical Trial.

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