Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Mar;100(3):141-143.
doi: 10.1111/imcb.12518. Epub 2021 Dec 28.

ILC2-derived IL-13 promotes skin cDC2 diversity

Affiliations
Comment

ILC2-derived IL-13 promotes skin cDC2 diversity

Stephen L Nutt et al. Immunol Cell Biol. 2022 Mar.

Abstract

In a new study, researchers have identified a new population of type 2 conventional dendritic cells in the skin that depend on IL-13 and promote Th2 mediated immunity.

PubMed Disclaimer

Comment on

References

    1. Mayer JU, Hilligan KL, Chandler JS, et al. Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization. Nat Immunol 2021; 22: 1538-1550.
    1. Anderson DA III, Dutertre CA, Ginhoux F, Murphy KM. Genetic models of human and mouse dendritic cell development and function. Nat Rev Immunol 2021; 21: 101-115.
    1. Nutt SL, Chopin M. Transcriptional networks driving dendritic cell differentiation and function. Immunity 2020; 52: 942-956.
    1. Tussiwand R, Everts B, Grajales-Reyes G, et al. Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity 2015; 42: 916-928.
    1. Malissen B, Tamoutounour S, Henri S. The origins and functions of dendritic cells and macrophages in the skin. Nat Rev Immunol 2014; 14: 417-428.

LinkOut - more resources