ILC2-derived IL-13 promotes skin cDC2 diversity
- PMID: 34962666
- DOI: 10.1111/imcb.12518
ILC2-derived IL-13 promotes skin cDC2 diversity
Abstract
In a new study, researchers have identified a new population of type 2 conventional dendritic cells in the skin that depend on IL-13 and promote Th2 mediated immunity.
© 2021 Australian and New Zealand Society for Immunology, Inc.
Comment on
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Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization.Nat Immunol. 2021 Dec;22(12):1538-1550. doi: 10.1038/s41590-021-01067-0. Epub 2021 Nov 18. Nat Immunol. 2021. PMID: 34795444
References
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- Malissen B, Tamoutounour S, Henri S. The origins and functions of dendritic cells and macrophages in the skin. Nat Rev Immunol 2014; 14: 417-428.
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