Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb;19(2):e202100618.
doi: 10.1002/cbdv.202100618. Epub 2021 Dec 29.

Antifouling Diterpenoids from the Sponge Dendrilla antarctica

Iván M Prieto  1   2 , Analía Paola  3   4 , Miriam Pérez  3   4 , Mónica García  3 , Guillermo Blustein  3   5 , Laura Schejter  6 , Jorge A Palermo  1   2
Affiliations

Antifouling Diterpenoids from the Sponge Dendrilla antarctica

Iván M Prieto et al. Chem Biodivers. 2022 Feb.

Abstract

Two nor-diterpenes, 9,11-dihydrogracilin A (1) and the previously unreported 9,11-dihydrogracillinone A (2), were isolated from the sponge Dendrilla antarctica. The sponge was collected by trawling at a depth of 49 m, from the research vessel Puerto Deseado, near the coast of Tierra del Fuego, farther north than the reported habitat for this species. Since these compounds were particularly abundant and the sponge was free from epibionts, both 1 and 2 were included in soluble-matrix paints and tested for antifouling activity in the ocean. The results obtained from these experiments clearly indicated a potent antifouling activity for both compounds against a variety of colonizing organisms, and established a probable role as natural antifoulants for these abundant secondary metabolites and other structurally related compounds previously isolated from Dendrilla spp.

Keywords: Dendrilla antarctica; Tierra del Fuego; antifouling activity; marine sponges; terpenoids.

PubMed Disclaimer

References

    1. J. N. A. Hooper, R. W. M. Van Soest, ‘Systema Porifera - A Guide to the Classification of Sponges (in 2 Volumes)’, Kluwer Academic/Plenum, New York, 2002.
    1. S. Urban, M. S. Butler, R. J. Capon, ‘Lamellarins O and P: new aromatic metabolites from the Australian marine sponge Dendrilla cactos’, Aust. J. Chem. 1994, 47, 1919-1924.
    1. J. N. A. Hooper, L. Hobbs, ‘Lamellarins Q and R: new aromatic metabolites from an Australian marine sponge, Dendrilla cactos’, Aust. J. Chem. 1995, 48, 1491-1494.
    1. R. Liu, Y. Liu, Y. D. Zhou, D. G. Nagle, ‘Molecular-targeted antitumor agents. 15. neolamellarins from the marine sponge Dendrilla nigra inhibit hypoxia-inducible factor-1 activation and secreted vascular endothelial growth factor production in breast tumor cells’, J. Nat. Prod. 2007, 70, 1741-1745.
    1. M. M. K. Kumar, J. D. Naik, K. Satyavathi, H. Ramana, P. R. Varma, K. P. Nagasree, D. Smitha, D. V. Rao, ‘Denigrins A−C: new antitubercular 3,4-diarylpyrrole alkaloids from Dendrilla nigra’, Nat. Prod. Res. 2014, 28, 888-894.

LinkOut - more resources