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Multicenter Study
. 2022 Apr;29(4):1209-1217.
doi: 10.1111/ene.15236. Epub 2022 Jan 21.

Clinic and genetic predictors in response to erenumab

Chiara Zecca  1   2 , Sarah Cargnin  3 , Christoph Schankin  4 , Nadia Mariagrazia Giannantoni  1 , Michele Viana  1 , Isabella Maraffi  1 , Gianna Carla Riccitelli  1   2 , Shairin Sihabdeen  1 , Salvatore Terrazzino  3 , Claudio Gobbi  1   2
Affiliations
Multicenter Study

Clinic and genetic predictors in response to erenumab

Chiara Zecca et al. Eur J Neurol. 2022 Apr.

Abstract

Background and purpose: Erenumab (ERE) is the first anticalcitonin gene-related peptide receptor monoclonal antibody approved for migraine prevention. A proportion of patients do not adequately respond to ERE.

Methods: Prospective multicenter study involving 110 migraine patients starting ERE 70 mg monthly. Baseline socio-demographics and migraine characteristics, including mean monthly migraine days (MMDs), migraine-related burden (MIDAS [Migraine Disability Assessment scale] and Headache Impact Test-6), and use of abortive medications, during 3 months before and after ERE start were collected. Real-time polymerase chain reaction was used to determine polymorphic variants of calcitonin receptor-like receptor and receptor activity-modifying protein-1 genes. Logistic regression models were used to identify independent predictors for 50% responder patients (50-RESP) and 75% responder patients (75-RESP).

Results: At month 3, MMDs decreased from 17.2 to 9.2 (p < 0.0001), 59/110 (53.6%) patients were 50-RESP, and 30/110 (27.3%) were 75-RESP. Age at migraine onset (odds ratio [OR] [95% confidence interval (95% CI)]: 1.062 [1.008-1.120], p = 0.024), number of failed preventive medications (0.753 [0.600-0.946], p = 0.015), and MIDAS score (1.011 [1.002-1.020], p = 0.017) were associated with 75-RESP. Among the genetic variants investigated, RAMP1 rs7590387 was found associated with a lower probability of being 75-RESP (per G allele OR [95% CI]: 0.53 [0.29-0.99], p = 0.048]), but this association did not survive adjustment for confounding clinical variables (per G allele, 0.55 [0.28-1.10], p = 0.09]).

Conclusions: In this real-word study, treatment with ERE significantly reduced MMDs. The number of failed preventive medications, migraine burden, and age at migraine onset predicted response to ERE. Larger studies are required to confirm a possible role of RAMP1 rs7590387 as genetic predictor of ERE efficacy.

Keywords: anti-CGRP antibodies; erenumab; predictors; treatment response.

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Conflict of interest statement

The authors declared the following potential conflicts of interest with the respect to the research, authorship, and/or publication of this article: the employer of C.Z. receives support for advisor activities, speaking, or grants from Celgene, Genzyme, Lilly, Merck, Novartis, Roche, and grants from Abbvie, Almirall, Biogen Idec, Celgene, Genzyme, Lilly, Merck, Novartis, Roche, Teva Pharma. C.S. reports scientific support, travel support, and/or honoraria from Novartis, Eli Lilly, TEVA Pharmaceuticals, Lundbeck, Allergan, Almirall, Amgen, MindMed, Grünenthal. C.S. is a part‐time employee at Zynnon. C.S. received research grants from German Migraine and Headache Society, Eye on Vision Foundation, and Baasch Medicus Foundation. The employer of C.G. receives support for advisor activities, speaking or grants from Celgene, Genzyme, Lilly, Merck, Novartis, Roche, and grants from Abbvie, Almirall, Biogen Idec, Celgene, Genzyme, Lilly, Merck, Novartis, Roche, Teva Pharma. S.C., G.C.R., S.T., M.V., N.M.G., I.M., and S.S. have no conflicts of interest to declare.

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References

    1. Dodick DW. Migraine. Lancet. 2018;391(10127):1315‐1330. - PubMed
    1. Sprenger T, Viana M, Tassorelli C. Current prophylactic medications for migraine and their potential mechanisms of action. Neurotherapeutics. 2018;15(2):313‐323. - PMC - PubMed
    1. Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol. 1990;28(2):183‐187. - PubMed
    1. Goadsby PJ, Edvinsson L. The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol. 1993;33(1):48‐56. - PubMed
    1. Lassen LH, Haderslev PA, Jacobsen VB, Iversen HK, Sperling B, Olesen J. CGRP may play a causative role in migraine. Cephalalgia. 2002;22(1):54‐61. - PubMed

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