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. 2021 Dec 29;16(12):e0260952.
doi: 10.1371/journal.pone.0260952. eCollection 2021.

Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context

Healthy Brain Study consortium  1   2   3 ; Esther Aarts  4 , Agnes Akkerman  5 , Mareike Altgassen  6 , Ronald Bartels  2 , Becky Beckers  7 , Kirsten Bevelander  2 , Erik Bijleveld  7 , Esmeralda Blaney Davidson  2 , Annemarie Boleij  2 , Janita Bralten  2 , Toon Cillessen  7 , Jurgen Claassen  2 , Roshan Cools  8 , Ineke Cornelissen  2 , Martin Dresler  8 , Thijs Eijsvogels  2 , Myrthe Faber  8 , Guillén Fernández  8 , Bernd Figner  4   7 , Matthias Fritsche  4 , Sascha Füllbrunn  5 , Surya Gayet  4 , Marleen M. H. J. van Gelder  2 , Marcel van Gerven  4 , Sabine Geurts  7 , Corina U. Greven  8 , Martine Groefsema  7 , Koen Haak  8 , Peter Hagoort  3   4 , Yvonne Hartman  2 , Beatrice van der Heijden  5 , Erno Hermans  8 , Vivian Heuvelmans  2 , Florian Hintz  3 , Janet den Hollander  2 , Anneloes M. Hulsman  4   7 , Sebastian Idesis  9 , Martin Jaeger  2 , Esther Janse  10 , Joost Janzing  2 , Roy P. C. Kessels  4   8 , Johan C. Karremans  7 , Willemien de Kleijn  11 , Marieke Klein  2 , Floris Klumpers  4   7 , Nils Kohn  8 , Hubert Korzilius  5 , Bas Krahmer  2 , Floris de Lange  4 , Judith van Leeuwen  8 , Huaiyu Liu  7 , Maartje Luijten  7 , Peggy Manders  2 , Katerina Manevska  5 , José P. Marques  4 , Jon Matthews  2 , James M. McQueen  4 , Pieter Medendorp  4 , René Melis  2 , Antje Meyer  3 , Joukje Oosterman  4 , Lucy Overbeek  2 , Marius Peelen  4 , Jean Popma  12 , Geert Postma  13 , Karin Roelofs  4   7 , Yvonne G. T. van Rossenberg  5 , Gabi Schaap  7 , Paul Scheepers  2 , Luc Selen  4 , Marianne Starren  10 , Dorine W. Swinkels  2 , Indira Tendolkar  8 , Dick Thijssen  2 , Hans Timmerman  14 , Rayyan Tutunji  8 , Anil Tuladhar  8 , Harm Veling  7 , Maaike Verhagen  7 , Jasper Verkroost  2 , Jacqueline Vink  7 , Vivian Vriezekolk  2 , Janna Vrijsen  8 , Jana Vyrastekova  5 , Selina van der Wal  2 , Roel Willems  4   10 , Arthur Willemsen  2
Affiliations

Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context

Healthy Brain Study consortium et al. PLoS One. .

Erratum in

  • Correction: Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context.
    Healthy Brain Study consortium; Aarts E, Akkerman A, Altgassen M, Bartels R, Beckers D, Bevelander K, Bijleveld E, Davidson EB, Boleij A, Bralten J, Cillessen T, Claassen J, Cools R, Cornelissen I, Dresler M, Eijsvogels T, Faber M, Fernández G, Figner B, Fritsche M, Füllbrunn S, Gayet S, van Gelder MMHJ, Gerven MV, Geurts S, Greven CU, Groefsema M, Haak K, Hagoort P, Hartman Y, van der Heijden B, Hermans E, Heuvelmans V, Hintz F, Hollander JD, Hulsman AM, Idesis S, Jaeger M, Janse E, Janzing J, Kessels RPC, Karremans JC, Kleijn W, Klein M, Klumpers F, Kohn N, Korzilius H, Krahmer B, Lange F, Leeuwen JV, Liu H, Luijten M, Manders P, Manevska K, Marques JP, Matthews J, McQueen JM, Medendorp P, Melis R, Meyer A, Oosterman J, Overbeek L, Peelen M, Popma J, Postma G, Roelofs K, van Rossenberg YGT, Schaap G, Scheepers P, Selen L, Starren M, Swinkels DW, Tendolkar I, Thijssen D, Timmerman H, Tutunji R, Tuladhar A, Veling H, Verhagen M, Verkroost J, Vink J, Vriezekolk V, Vrijsen J, Vyrastekova J, Wal SV, Willems R, Willemsen A. Healthy Brain Study consortium, et al. PLoS One. 2022 Apr 11;17(4):e0267071. doi: 10.1371/journal.pone.0267071. eCollection 2022. PLoS One. 2022. PMID: 35404975 Free PMC article.

Abstract

The endeavor to understand the human brain has seen more progress in the last few decades than in the previous two millennia. Still, our understanding of how the human brain relates to behavior in the real world and how this link is modulated by biological, social, and environmental factors is limited. To address this, we designed the Healthy Brain Study (HBS), an interdisciplinary, longitudinal, cohort study based on multidimensional, dynamic assessments in both the laboratory and the real world. Here, we describe the rationale and design of the currently ongoing HBS. The HBS is examining a population-based sample of 1,000 healthy participants (age 30-39) who are thoroughly studied across an entire year. Data are collected through cognitive, affective, behavioral, and physiological testing, neuroimaging, bio-sampling, questionnaires, ecological momentary assessment, and real-world assessments using wearable devices. These data will become an accessible resource for the scientific community enabling the next step in understanding the human brain and how it dynamically and individually operates in its bio-social context. An access procedure to the collected data and bio-samples is in place and published on https://www.healthybrainstudy.nl/en/data-and-methods/access. Trail registration: https://www.trialregister.nl/trial/7955.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The Polymorphic Encryption and Pseudonymization (PEP) infrastructure.
Fig 2
Fig 2. Design of data collection in the healthy brain study.
Fig 3
Fig 3. Progress and milestones of the healthy brain study.
See this image and copyright information in PMC

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