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. 2021 Dec 20:2021:3574321.
doi: 10.1155/2021/3574321. eCollection 2021.

Network Pharmacology Study on Molecular Mechanisms of Zhishi Xiebai Guizhi Decoction in the Treatment of Coronary Heart Disease

Jin Gao  1 , Yujing Pan  2 , Yuxi Zhao  3 , Haoyang Li  4 , Zishuo Mi  5 , Hao Chen  2 , Xiaodong Tan  6
Affiliations

Network Pharmacology Study on Molecular Mechanisms of Zhishi Xiebai Guizhi Decoction in the Treatment of Coronary Heart Disease

Jin Gao et al. Evid Based Complement Alternat Med. .

Abstract

Background: Coronary heart disease is characterized by the formation of arterial plaque. If not taken seriously, it will cause serious consequences such as myocardial infarction and heart failure. Zhishi Xiebai Guizhi Decoction first appeared in "Synopsis of Prescriptions of the Golden Chamber" and is a representative prescription for the treatment of coronary heart disease. This study aims to explain the mechanism of Zhishi Xiebai Guizhi Decoction in the treatment of coronary heart disease through network pharmacology and clinical trials.

Methods: We first identified the core compounds of Zhishi Xiebai Guizhi Decoction and their potential targets through TCMSP. Then, We analyzed the molecular targets of Zhishi Xiebai Guizhi Decoction in coronary heart disease with OMIM and GeneCards databases. After the common targets were screened out, we manage to figure out the pathways of these target genes through STRING. Finally, we verify the treatment results in clinical trials.

Results: Through network pharmacology analysis, we discovered that several core compounds of Zhishi Xiebai Guizhi Decoction have anti-inflammatory effects and are of great significance to treatment of cardiovascular diseases. The mechanism may be closely related to PPARγ, inflammation, TNF signaling pathway, AMPK signaling pathway, and PI3K-Akt signaling pathway. Clinical trials have also proved the key role of inflammation.

Conclusions: Zhishi Xiebai Guizhi Decoction may play a role in treating coronary heart disease by activating PPARγ. TNF signaling pathway, AMPK signaling pathway, and PI3K-Akt signaling pathway are potential mechanisms as well. The application of network pharmacology can provide a novel method for the research of Chinese herbal medicine. We hope that Zhishi Xiebai Guizhi Decoction will be recognized as a complementary or alternative treatment for coronary heart disease.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
The whole framework based on an integration strategy of network pharmacology.
Figure 2
Figure 2
The network diagram of the compound and the target protein.
Figure 3
Figure 3
Venn diagram of targets of Zhishi Xiebai Guizhi Decoction in treating coronary heart disease.
Figure 4
Figure 4
Network diagram of intersection targets of Zhishi Xiebai Guizhi Decoction in the treatment of coronary heart disease.
Figure 5
Figure 5
The protein-protein interaction network of Zhishi Xiebai Guizhi Decoction in the treatment of coronary heart disease.
Figure 6
Figure 6
GO biological process enrichment analysis.
Figure 7
Figure 7
KEGG enrichment analysis.
Figure 8
Figure 8
Clinical trial results.
See this image and copyright information in PMC

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