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Comparative Study
. 2021 Dec 1;22(12):3933-3939.
doi: 10.31557/APJCP.2021.22.12.3933.

Hypofractionated Hybrid Radiotherapy Techniques for Synchronous Bilateral Breast Cancer

Karunakaran Balaji  1   2 , Velayudham Ramasubramanian  1
Affiliations
Comparative Study

Hypofractionated Hybrid Radiotherapy Techniques for Synchronous Bilateral Breast Cancer

Karunakaran Balaji et al. Asian Pac J Cancer Prev. .

Abstract

Objective: This study intends at a dosimetric comparison of four different hybrid plans which is a combination of different radiation therapy techniques, for synchronous bilateral breast cancer (SBBC) irradiation using a hypofractionated dose regimen.

Methods: Four different hybrid techniques: 3DCRT+IMRT, 3DCRT+VMAT, IMRT+VMAT, and VMAT+IMRT were planned using computed tomography (CT) images of fifteen SBBC patients. All hybrid plans were generated using a hypofractionated dose prescription of 40.5 Gy in 15 fractions. 70% of the dose was planned with a base-dose component and the remaining 30% of the dose was planned with a hybrid component. The plans were evaluated based on the PTV and organs at risk (OARs) dosimetric parameter results and computed a plan quality score for each plan.

Results: The results for PTV parameters have shown that the 3DCRT+VMAT and 3DCRT+IMRT plans were better than other plans. The 3DCRT±IMRT plan was provided better results for OARs, while IMRT±VMAT and VMAT+IMRT plans were increased the low dose volumes to the heart and lungs. The 3DCRT+VMAT plan was required less monitor units and treatment time compared to other plans.

Conclusion: The overall plan quality score that integrated the dosimetric parameters of PTV and OARs indicated that the 3DCRT+VMAT hybrid plan is superior for SBBC treatment.

Keywords: Bilateral breast cancer; Hypofractionation; IMRT; VMAT; hybrid plans.

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Figures

Figure 1
Figure 1
(a) Location of isocenter, (b) field arrangement in base-dose 3DCRT and IMRT plans, and (c) field arrangement in base-dose VMAT plan
Figure 2
Figure 2
Field Arrangements in (a) IMRT Plan (5 fields for each breast), (b) VMAT Plan (2 partial and 2 tangential Arcs for Each Breast)
See this image and copyright information in PMC

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