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. 2022 Sep-Oct;33(5):308-322.
doi: 10.1097/DER.0000000000000817. Epub 2021 Dec 30.

The Association Between Allergic Contact Dermatitis and Erythema Multiforme: A Systematic Review of the Literature

Alison H Kohn  1 , Sarah P Pourali  2 , Brandon L Adler  3 , April W Armstrong  3
Affiliations

The Association Between Allergic Contact Dermatitis and Erythema Multiforme: A Systematic Review of the Literature

Alison H Kohn et al. Dermatitis. 2022 Sep-Oct.

Abstract

The relationship between erythema multiforme (EM) and allergic contact dermatitis (ACD) remains unclear. There have been multiple reports of EM-like lesions occurring in conjunction with or presenting after ACD; however, various definitions and terminologies have been used to denote the patient's diagnosis in these cases. In this systematic review, we summarize the key presenting features of recent cases of EM-like eruptions associated with ACD, as well as diagnostic findings, responsible allergens, treatments, and outcomes. We propose that, whenever possible, these cases should be classified into 2 distinct categories: (1) EM-like ACD and (2) EM after ACD (ACD-induced EM). Because the clinical courses, potential complications, and treatment plans differ between the two, a critical need exists for further characterization and distinguishment of EM-like ACD and ACD-induced EM.

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Conflict of interest statement

B.L.A. has served as a research investigator and/or scientific advisor to AbbVie and Skin Research Institute, LLC. A.W.A. has served as a research investigator and/or scientific advisor to AbbVie, ASLAN, BI, BMS, EPI, Incyte, Leo, UCB, Janssen, Lilly, Novartis, Ortho Dermatologics, Sun, Dermavant, Dermira, Sanofi, Regeneron, Pfizer, and Modmed. The remaining authors have no funding or conflicts of interest to declare.

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