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Review
. 2022 Feb 1;34(1):10-14.
doi: 10.1097/GCO.0000000000000760.

Cell-based immunotherapies in gynecologic cancers

Affiliations
Review

Cell-based immunotherapies in gynecologic cancers

Susan M Lang et al. Curr Opin Obstet Gynecol. .

Abstract

Purpose of review: This review provides an update on recent developments in cell-based immunotherapy in gynecologic cancers.

Recent findings: Chimeric antigen receptor (CAR) technology has made significant progress allowing now for not only expressing CARs on T-cells, but also on other immune effector cells, such as natural killer cells and macrophages. Cell-based vaccines have started to show promising results in clinical trials.

Summary: Cell-based immunotherapies in gynecologic cancers continue to evolve with promising clinical efficacy in select patients.

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References

    1. Baci D, Bosi A, Gallazzi M, et al. The Ovarian Cancer Tumor Immune Microenvironment (TIME) as target for therapy: a focus on innate immunity cells as therapeutic effectors. Int J Mol Sci 2020; 21:3125.
    1. Weber EW, Maus MV, Mackall CL. The emerging landscape of immune cell therapies. Cell 2020; 181:46–62.
    1. Zhang L, Conejo-Garcia JR, Katsaros D, et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 2003; 348:203–213.
    1. Hao J, Yu H, Zhang T, et al. Prognostic impact of tumor-infiltrating lymphocytes in high grade serous ovarian cancer: a systematic review and meta-analysis. Ther Adv Med Oncol 2020; 12: 1758835920967241.
    1. Santoiemma PP, Powell DJ Jr. Tumor infiltrating lymphocytes in ovarian cancer. Cancer Biol Ther 2015; 16:807–820.

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